ArticlePain management nursing : official journal of the American Society of Pain Management Nurses2026
Comorbid Conditions of Ehlers-Danlos Syndromes and Vulvodynia: A Latent Class Analysis.
Article in Pain management nursing : official journal of the American Society of Pain Management Nurses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
purposeHaving an Ehlers-Danlos syndrome (EDS) or hypermobility spectrum disorder (HSD) may increase the likelihood of vulvodynia six-fold. Studying vulvodynia in EDS/HSD may help identify causes of vulvodynia and potential treatments. Currently there are no consistently effective treatment methods for vulvodynia. We aim to identify comorbid condition patterns and how they affect a participant's likelihood of screening positive for vulvodynia.
designOnline survey.
methodsA secondary analysis was conducted using latent class analysis on data from females aged ≥18 years with EDS or HSD (N = 1,016) who were screened for vulvodynia.
resultsFive comorbid condition patterns of 9 indicators were identified. Among the patterns 2 overarching comorbid condition phenotypes were present, 1) non-musculoskeletal phenotype (n = 185) comprised of mast cell activation disorder, gastrointestinal conditions, and dysautonomia; and 2) pain phenotype (n = 442) comprised of chronic pain and pelvic instability; 201 participants endorsed both phenotypes. The non-musculoskeletal phenotype incurred the smallest likelihood of screening positive, followed by the pain phenotype. Endorsed both phenotypes resulted in significantly greater likelihood of screening vulvodynia positive (p < 0.05) compared to one phenotype.
conclusionsPhenotypes may constitute 1) different pathways for developing vulvodynia and/or 2) different subtypes of vulvodynia and/or EDS. We hypothesize that as a person accumulates comorbid conditions, their allostatic load increases, and once a personal allostatic load threshold is crossed, vulvodynia may develop. CLINICAL IMPLICATIONS: Different pathways for developing vulvodynia may explain why there is no consistently effective treatment for vulvodynia. Phenotypes may be able to be used to develop personalized treatment methods.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.