ArticleVirus research2026
Circulating miR-146a-5p and miR-98-5p as Indicators of Inflammatory Response and Joint Pain in Chikungunya Fever.
Article in Virus research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesChikungunya virus (CHIKV) infection often results in chronic manifestations such as joint pain and fatigue. Recent evidence suggests that host microRNAs (miRNAs) may modulate antiviral and inflammatory responses during infection. This study aimed to investigate serum expression patterns of inflammation-related miRNAs in Chikungunya patients and to explore their association with disease severity, particularly arthralgia.
methodsA total of 55 laboratory-confirmed Chikungunya patients and 55 healthy controls were enrolled. Clinical characteristics and hematological parameters were recorded, and serum samples were collected for miRNA extraction. The expression levels of five selected miRNAs (miR-10a-5p, miR-21-5p, miR-98-5p, miR-146a-5p, and miR-155a-5p) were quantified by real-time PCR. Statistical analyses and receiver operating characteristic (ROC) curve evaluations were performed to assess differential expression and diagnostic performance. Additionally, subgroup analysis was conducted based on the presence or absence of arthralgia.
resultsCompared with healthy controls, Chikungunya patients exhibited marked hematological alterations, including reduced WBC, LYM, RBC, HGB, HCT, and PLT counts, as well as elevated AISI and serum AST and LDH levels, indicating a strong systemic inflammatory response. Among the analyzed miRNAs, miR-146a-5p was significantly upregulated (P < 0.0001), while miR-98-5p was markedly downregulated (P = 0.0007) in infected patients. ROC analysis demonstrated that miR-146a-5p (area under the curve, AUC = 0.77) and miR-98-5p (AUC = 0.69) possess promising diagnostic potential. Notably, miR-98-5p expression was significantly lower in patients with arthralgia compared with those without (P = 0.0187), suggesting its involvement in joint inflammatory manifestations.
conclusionThis study found that Chikungunya virus infection significantly alters serum miRNA expression, with miR-146a-5p and miR-98-5p potentially associated with systemic inflammation and joint pain. These findings suggest that both miRNAs play important roles in the host inflammatory response and may serve as potential diagnostic or therapeutic targets for Chikungunya-related complications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.