Evidence map›Paper›PMID 41966328›Full record

ArticleTumour virus research2026

Oncolytic virus hijacks GOT1 and pyrimidinosomes to fuel pyrimidine synthesis for replication in tumor cells.

Ning Tang, Yabin Gong, Changrun Zhao, Yujia Niu, Lei Tan, Cuiping Song, Xusheng Qiu, Ying Liao, Shengqing Yu, Chan Ding and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tumour virus research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ning TangShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, PR China; School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, PR China.
Yabin GongShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, PR China.
Changrun ZhaoShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, PR China; College of Animal Science and Technology, Guangxi University, Nanning, 530004, PR China.
Yujia NiuState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, PR China.
Lei TanShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, PR China.
Cuiping SongShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, PR China.
Xusheng QiuShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, PR China.
Ying LiaoShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, PR China.
Shengqing YuShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, PR China.
Chan DingShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, PR China; School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, PR China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou, PR China. Electronic address: shoveldeen@shvri.ac.cn.
Shuhai LinState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, PR China. Electronic address: shuhai@xmu.edu.cn.
Yingjie SunShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, PR China. Electronic address: sunyingjie@shvri.ac.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oncolytic viruses selectively infect and kill tumor cells, but the metabolic adaptations that support their replication remain incompletely understood. Here, using oncolytic Newcastle disease virus (NDV) as a model, we identify glutamic-oxaloacetic transaminase 1 (GOT1) as a key metabolic enzyme required for efficient viral replication through its dual role in de novo pyrimidine synthesis. In NDV-infected tumor cells, GOT1 promotes aspartate production through the malate-aspartate shuttle to support pyrimidine biosynthesis, while also maintaining NAD

Indexed as

NeoplasmsNewcastle disease virusOncolytic VirusesPyrimidinesVirus ReplicationAnimalsAspartate CarbamoyltransferaseAspartic AcidCarbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)Cell Line, TumorDihydroorotaseHumansMalatesNADOncolytic VirotherapySignal TransductionAspartate CarbamoyltransferaseAspartic AcidCAD trifunctional enzymeCarbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)DihydroorotaseNADpyrimidinePyrimidinesTOR Serine-Threonine KinasesCADGOT1NAD(+)/NADHOncolytic newcastle disease virusPyrimidine synthesisPyrimidinosome

Identifiers

PMID41966328
PMCPMC13092059

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.