Rhodium-Catalyzed Desymmetric Addition of Boronic Acids to Malononitriles.

Minghao Zhang, Qihao Zhang, Junjie Cao, Jun Joelle Wang, Jianchun Wang, Zhongxing Huang

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Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Minghao ZhangState Key Laboratory of Synthetic Chemistry, Shanghai Hong Kong Joint Laboratory in Chemical Synthesis, Department of Chemistry, The University of Hong Kong, Hong Kong, China.

Qihao ZhangState Key Laboratory of Synthetic Chemistry, Shanghai Hong Kong Joint Laboratory in Chemical Synthesis, Department of Chemistry, The University of Hong Kong, Hong Kong, China.

Junjie CaoShenzhen Grubbs Institute and Department of Chemistry, Guangming Advanced Research Institute, and Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen 518055, China.

Jun Joelle WangDepartment of Chemistry, Hong Kong Baptist University, Kowloon, Hong Kong, China.ORCID 0000-0001-9723-4054

Jianchun WangShenzhen Grubbs Institute and Department of Chemistry, Guangming Advanced Research Institute, and Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen 518055, China.ORCID 0000-0002-3998-8699

Zhongxing HuangState Key Laboratory of Synthetic Chemistry, Shanghai Hong Kong Joint Laboratory in Chemical Synthesis, Department of Chemistry, The University of Hong Kong, Hong Kong, China.ORCID 0000-0003-0196-3469

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malononitrile is a privileged chemical feedstock for building complex nitrogen-containing molecules of interest. However, achieving high enantiocontrol in transformations of its derivatives is often challenging, as the spatial arrangement of the two linear nitriles impedes the chelative assistance commonly exploited in related multifunctionalized reactants. Here, we demonstrate a customized phosphoramidite ligand for a rhodium-catalyzed desymmetric addition of carbon nucleophiles to malononitriles. The chiral pocket, enclosed by a vaulted, chlorinated binaphthol skeleton and an iminostilbene motif, is proposed to restrict the C(

Identifiers

PMID41966114

DOI10.1021/jacs.5c23045

PMCPMC13107447

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