Evidence map›Paper›PMID 41966053›Full record

ReviewPlant communications2026

AI-driven fungicide design: From target identification to field application.

Hong Hu, Zhiguang Qu, Yuanlong Liu, Lida Zhu, Zhinan Mei, Xiao-Lin Chen

Abstract readReview
In one paragraph

Review in Plant communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Decoding the rhizosphere microbiome againstFrontiers in microbiomes · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hong HuState Key Laboratory of Agricultural Microbiology and Provincial Key Laboratory of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Zhiguang QuState Key Laboratory of Agricultural Microbiology and Provincial Key Laboratory of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Yuanlong LiuState Key Laboratory of Agricultural Microbiology and Provincial Key Laboratory of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Lida ZhuCollege of Informatics, Huazhong Agricultural University, Wuhan 430070, China. Electronic address: ldzhu@mail.hzau.edu.cn.
Zhinan MeiState Key Laboratory of Agricultural Microbiology and Provincial Key Laboratory of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, China. Electronic address: meizhinan@163.com.
Xiao-Lin ChenState Key Laboratory of Agricultural Microbiology and Provincial Key Laboratory of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, China. Electronic address: chenxiaolin@mail.hzau.edu.cn.

Funding

Non-US Government Research Support type
6 · The paper itself

Abstract

Plant pathogenic fungi pose a severe threat to global agriculture, causing substantial yield losses in staple crops and jeopardizing food safety through mycotoxin contamination. Conventional fungicide development is hindered by high costs, lengthy timelines, and the rapid evolution of fungal resistance, which outpaces conventional discovery workflows. Although artificial intelligence (AI) offers transformative potential to address these bottlenecks, its application in plant pathology remains fragmented and lacks integration of agriculture-specific constraints such as field stability, ecological safety, and resistance management. This review introduces the AI-driven fungicide design (AIFD) platform, a comprehensive framework comprising four interdependent components: a plant pathogen-specific data ecosystem, a modular microservice technical architecture, a linear multiphase development workflow, and a specialized resistance prediction workflow. We synthesize key technological advances across the fungicide development pipeline, from target identification and virtual screening to molecular optimization and field validation, with an emphasis on AI methodologies adapted to agrochemical requirements rather than pharmaceutical standards. Despite substantial advances, critical challenges persist, including scarce high-quality training data for understudied pathogens, limited model adaptability across diverse agroecosystems, poor interpretability that hinders stakeholder trust, and accessibility barriers for resource-constrained researchers. Future directions emphasize the integration of real-time field data, explainable AI to facilitate regulatory acceptance, and inclusive design strategies aimed at bridging the laboratory-to-field gap. By aligning computational innovation with agricultural priorities, AIFD platforms can accelerate the discovery of resistance-breaking, environmentally benign fungicides, thus offering a viable pathway toward sustainable crop protection and enhanced global food security.

Indexed as

Artificial IntelligenceDrug DesignFungiFungicides, IndustrialPlant DiseasesAgricultureCrops, AgriculturalDrug Resistance, FungalFungicides, Industrialartificial intelligencefungicide developmentplant pathogenic fungiresistance predictionsustainable agriculture

Identifiers

PMID41966053
PMCPMC13174260

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.