Evidence map›Paper›PMID 41965938›Full record

ArticleBritish journal of cancer2026

Methylation biomarkers in non-regressive cervical intraepithelial neoplasia grade 2 lesions: an epigenome wide association study.

Laura Burney Ellis, Sarah J Bowden, Maria Paraskevaidi, Deirdre Lyons, Evangelos Paraskevaidis, Anna-Barbara Moscicki, James M Flanagan, Maria Kyrgiou

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Laura Burney Ellis *Department of Metabolism, Digestion and Reproduction, IRDB, Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK.
Sarah J Bowden *Department of Metabolism, Digestion and Reproduction, IRDB, Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK.
Maria ParaskevaidiDepartment of Metabolism, Digestion and Reproduction, IRDB, Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK.
Deirdre LyonsImperial College Healthcare NHS Trust, Hammersmith Hospital, London, Du Cane Road, London, W12 0HS, UK.
Evangelos ParaskevaidisDepartment of Obstetrics and Gynaecology, University of Ioannina, Ioannina, Greece.
Anna-Barbara MoscickiDivision of Paediatrics, University of California, Los Angeles, USA.
James M FlanaganDepartment of Surgery & Cancer, IRDB, Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK.
Maria KyrgiouDepartment of Metabolism, Digestion and Reproduction, IRDB, Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK. m.kyrgiou@imperial.ac.uk.ORCID http://orcid.org/0000-0002-7165-0735

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDNA methylation has been proposed as a predictive biomarker. Cervical intraepithelial neoplasia grade 2 (CIN2) was historically the cut-off for surgical treatment, however it is increasingly managed with active surveillance, while there is currently no accurate way to predict which lesions will regress.

methodsWe performed the first Illumina 850k array on DNA from serial liquid based-cytology cervical samples from young women with CIN2 that were managed with active surveillance (n = 58). Linear regression identified differentially-methylated sites at baseline distinguishing regressors from non-regressors with persistent or progressive disease at 24-months. Associations with imminent regression and histological change were also evaluated.

resultsWe identified three novel differentially-methylated sites; cg12754953 (ALDH9A1) methylation was significantly increased at baseline in non-regressors, cg18887759 (MED25) methylation was significantly lower in samples from women who regressed within the subsequent 12 months, and cg13556949 (TULP2) methylation increased over time between baseline and 12-months of follow-up in non-regressors as compared to regressors.

conclusionMethylation could help guide treatment decisions in women considering active surveillance of CIN2 lesions. ALDH9A1, MED25 and TULP2 may be implicated as genes with possible roles in host response to viral mechanisms. Larger prospective studies are needed to validate these findings.

Indexed as

Biomarkers, TumorEpigenomeUterine Cervical DysplasiaAdolescentAldehyde DehydrogenaseCervix UteriDisease ProgressionDNA MethylationEye ProteinsFemaleFollow-Up StudiesGenome-Wide Association StudyHumansMediator ComplexNeoplasm GradingWatchful WaitingAldehyde DehydrogenaseALDH9A1 protein, humanBiomarkers, TumorEye ProteinsMED25 protein, humanMediator ComplexTULP2 protein, human

Identifiers

PMID41965938
PMCPMC13269546

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.