Evidence map›Paper›PMID 41965913›Full record

ArticleVeterinary medicine and science2026

Use of Pentoxifylline to Improve Seminal Parameters in Dogs.

Vincenzo Cicirelli, Matteo Burgio, Lorenza Frattina, Francesco Caprio, Domenico Robbe, Federica Ariu, Annalisa Rizzo

Abstract read
In one paragraph

Article in Veterinary medicine and science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Vincenzo CicirelliDepartment of Veterinary Medicine, University of Bari, Valenzano, Italy.ORCID https://orcid.org/0000-0003-2792-8848
Matteo BurgioDepartment of Veterinary Medicine, University of Bari, Valenzano, Italy.ORCID https://orcid.org/0000-0002-8203-4540
Lorenza FrattinaDepartment of Veterinary Medicine, University of Bari, Valenzano, Italy.
Francesco CaprioDepartment of Veterinary Medicine, University of Bari, Valenzano, Italy.
Domenico RobbeDepartment of Veterinary Medicine, University of Teramo, Piano d'Accio, Teramo, Italy.
Federica AriuDepartment of Veterinary Medicine, University of Sassari, Sassari, Italy.
Annalisa RizzoDepartment of Veterinary Medicine, University of Bari, Valenzano, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe study aimed to evaluate the effect of a one-shot oral administration of pentoxifylline on semen parameters in normospermic and oligospermic dogs.

methodsTwenty-nine dogs were categorized as normospermic or oligospermic based on baseline sperm concentration. After 10 days from the first semen evaluation, each dog received 10 mg/kg of pentoxifylline orally, given 40 min prior to ejaculation. Semen was evaluated using a Computer-Assisted Sperm Analysis (CASA) system and Eosin-Nigrosin staining for vitality.

resultsCompared with baseline, pentoxifylline treatment resulted in a statistically significant increase in sperm concentration and progressive motility (p < 0.01), most notably in oligospermic dogs. CONCLUSION AND CLINICAL SIGNIFICANCE: These findings highlight the beneficial effects of pentoxifylline and confirm its potential as an adjunct therapy for improving semen quality in subfertile male dogs.

Indexed as

PentoxifyllineSemenSemen AnalysisSpermatozoaAnimalsDogsMaleSperm MotilityPentoxifyllinecanine semensperm motilitysperm parameterssperm viabilitysubfertility

Identifiers

PMID41965913
PMCPMC13070024

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.