ArticleNature communications2026
Skeletal editing of tetrahydrofurans to pyrrolidines through O-to-N single atom swap.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Formal nitrogen-to-carbon replacement in isoindolines to form indenesChemical science · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
Skeletal editing has emerged as a powerful strategy for organic synthesis, addressing a long-standing synthetic challenge between molecular scaffolds. In recent years, skeletal editing (insertion, deletion, and swap) undergoes rapid evolution and realizes many remarkable transformations between basic or complex molecular skeletons. Different from atom insertion and deletion reactions, atom swap reactions enable selective exchange of atoms in a single step. Among existing atom swap strategies, the editing of aromatic scaffolds has been extensively studied, while the editing of aliphatic scaffolds remains limited to only a few reports. Tetrahydrofuran rings, as one of the most common aliphatic scaffolds, are highly attractive targets for conversion into high-value pyrrolidines. Herein, we report a practical and straightforward method to convert tetrahydrofurans to N-acyl pyrrolidines using nitriles as the nitrogen source, achieving oxygen-to-nitrogen (O-to-N) atom swap in one step.
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Registered trials
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