Evidence map›Paper›PMID 41965829›Full record

ArticleJournal of cardiothoracic surgery2026

The effects of neoadjuvant chemoradiotherapy-related frailty by analytic morphomics in esophageal cancer.

Chien-Hung Chiu, Jules Lin, Peng Zhang, Andrew C Chang, Brian A Derstine, Brian E Ross, Binu Enchakalody, Nidhi V Shah, Yun-Hen Liu, Stewart C Wang and 1 more

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In one paragraph

Article in Journal of cardiothoracic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Chien-Hung ChiuDivision of Thoracic Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University, Taoyuan, Taiwan.
Jules LinSection of Thoracic Surgery, University of Michigan, Ann Arbor, MI, USA. juleslin@med.umich.edu.
Peng ZhangDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.
Andrew C ChangSection of Thoracic Surgery, University of Michigan, Ann Arbor, MI, USA.
Brian A DerstineDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.
Brian E RossDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.
Binu EnchakalodyDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.
Nidhi V ShahDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.
Yun-Hen LiuDivision of Thoracic Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University, Taoyuan, Taiwan.
Stewart C WangDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.
Yin-Kai ChaoDivision of Thoracic Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University, Taoyuan, Taiwan. chaoyk@cgmh.org.tw.

Funding

Developing Personalized Treatment for Diabetes Through Novel Imaging MethodsK01DK106296 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZHANG, PENG · 2016 to 2018
$465k
Chang Gung Memorial Hospital, Linkou CORPG5H0021NIH HHS K01 DK106296
6 · The paper itself

Abstract

backgroundNeoadjuvant chemoradiotherapy followed by surgery offers potential cure for locally advanced esophageal cancer. Yet, frailty often emerges post-therapy, heightening risks of delayed surgery and complications. Analytic morphomics, derived from computed tomography scans, quantifies body composition, reflecting nutritional and functional status. Our study delineates morphomic shifts post-neoadjuvant chemoradiotherapy and their impact on short-term outcomes.

methodsWe retrospectively analyzed patients with esophageal cancer treated with neoadjuvant chemoradiotherapy followed by esophagectomy between 2007 and 2016. Clinical and morphomic data pre- and post- neoadjuvant chemoradiotherapy were collected, and changes were identified using paired comparisons. Delayed surgery and postoperative complications were evaluated using univariate and multivariable analyses.

resultsThe study included 181 patients with esophageal cancer who received neoadjuvant chemoradiotherapy followed by surgery. Decreased bone mineral density, dorsal muscle group area and visceral adipose tissue area (all p < 0.001) were noted after neoadjuvant chemoradiotherapy. On multivariable Cox regression, a greater increase in subcutaneous fat area after neoadjuvant chemoradiotherapy (p = 0.04) was associated with delayed surgery. Increasing age was associated with overall (p = 0.03) and medical (p = 0.006) postoperative complications while a greater decrease in dorsal muscle group area after neoadjuvant chemoradiotherapy (p = 0.046) was associated with surgical complications.

conclusionsBody composition changes significantly after neoadjuvant chemoradiotherapy for esophageal cancer, indicating increasing frailty. Advanced age correlated with medical complications, while reduced dorsal muscle group area post-neoadjuvant chemoradiotherapy was linked to surgical complications. Utilizing analytic morphomics to evaluate post-neoadjuvant chemoradiotherapy body composition changes helps predict short-term outcomes and may refine esophagectomy patient selection.

Indexed as

ChemoradiotherapyEsophageal NeoplasmsFrailtyNeoadjuvant TherapyAgedBody CompositionEsophagectomyFemaleHumansMaleMiddle AgedPostoperative ComplicationsRetrospective StudiesTomography, X-Ray ComputedAnalytic morphomicsBody compositionDelayed surgeryEsophageal cancerNeoadjuvant chemoradiotherapyPostoperative complications

Identifiers

PMID41965829
PMCPMC13214144

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.