Evidence map›Paper›PMID 41965712›Full record

ArticleBMC medical informatics and decision making2026

SOFA score combined with heart rate variability predicts in-hospital mortality in patients with intra-abdominal hypertension: a retrospective study.

Ninghan Qu, Jinqiang Zhuang, Chenchen Yuan, Keyan Wu, Qingtian Zhu, Xiaowu Dong, Weiwei Chen, Guotao Lu, Weiming Xiao, Xiaoping Yu

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Article in BMC medical informatics and decision making, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

10 authors.

Ninghan Qu *Pancreatic Center, Department of Gastroenterology, Yangzhou Key Laboratory of Pancreatic Disease, Institute of Digestive Diseases, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, 225100, China.
Jinqiang Zhuang *Department of Emergency Intensive Care Unit, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, 225100, China.
Chenchen Yuan *Pancreatic Center, Department of Gastroenterology, Yangzhou Key Laboratory of Pancreatic Disease, Institute of Digestive Diseases, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, 225100, China.
Keyan WuPancreatic Center, Department of Gastroenterology, Yangzhou Key Laboratory of Pancreatic Disease, Institute of Digestive Diseases, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, 225100, China.
Qingtian ZhuPancreatic Center, Department of Gastroenterology, Yangzhou Key Laboratory of Pancreatic Disease, Institute of Digestive Diseases, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, 225100, China.
Xiaowu DongPancreatic Center, Department of Gastroenterology, Yangzhou Key Laboratory of Pancreatic Disease, Institute of Digestive Diseases, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, 225100, China.
Weiwei ChenFaculty of Medicine, Yangzhou University, Yangzhou, Jiangsu, 225009, China.
Guotao LuPancreatic Center, Department of Gastroenterology, Yangzhou Key Laboratory of Pancreatic Disease, Institute of Digestive Diseases, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, 225100, China. gtlu@yzu.edu.cn.
Weiming XiaoPancreatic Center, Department of Gastroenterology, Yangzhou Key Laboratory of Pancreatic Disease, Institute of Digestive Diseases, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, 225100, China. wmxiao@yzu.edu.cn.
Xiaoping YuHealth Management Centre, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, 225100, China. xpyu@yzu.edu.cn.

Funding

National Natural Science Foundation of China 82370653
6 · The paper itself

Abstract

backgroundIntra-abdominal hypertension (IAH) is a life-threatening condition associated with increased morbidity and mortality in intensive care unit (ICU) patients. Autonomic nervous system dysfunction, reflected by altered heart rate variability (HRV), has shown prognostic significance in critical illness. This study aimed to evaluate the prognostic value of HRV in predicting mortality among IAH patients.

methodsIn the Medical Information Mart for Intensive Care III (MIMIC-III) database, we retrospectively identified adult ICU patients who had both intra-abdominal pressure (IAP) measurements and electrocardiogram (ECG) recordings available. According to IAP measurements, patients were divided into a normal IAP (N-IAP) group and an IAH group. Twelve HRV parameters were derived from RR intervals. A multivariable logistic regression model including both Sequential Organ Failure Assessment (SOFA) score and HRV variables was developed to predict in-hospital mortality. Model performance was evaluated using receiver operating characteristic (ROC) curves and area under the curve (AUC), and was compared with a SOFA-only model. Internal validation was performed using bootstrap resampling.

resultsAmong 202 patients, HRV was significantly lower in the IAH group than in the N-IAP group. Deceased IAH patients exhibited significantly lower HRV than survivors. The combined SOFA and HRV model achieved an AUC of 0.832 for predicting in-hospital mortality, which was higher than that of the SOFA-only model (AUC = 0.801).

conclusionsDiminished HRV is a critical prognostic marker for mortality in patients with IAH. Incorporating HRV into the SOFA-based model improves predictive performance for in-hospital mortality compared with the SOFA score alone.

Indexed as

Heart RateHospital MortalityIntra-Abdominal HypertensionOrgan Dysfunction ScoresAgedFemaleHumansIntensive Care UnitsMaleMiddle AgedPrognosisRetrospective StudiesAutonomic nervous system dysfunctionHeart rate variabilityIntra-abdominal hypertensionMortality predictionSOFA score

Identifiers

PMID41965712
PMCPMC13185316

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.