Evidence map›Paper›PMID 41965598›Full record

ArticleBMC musculoskeletal disorders2026

Biomechanical effects of a novel anatomic fusion cage for anterior cervical corpectomy: a finite element study.

Zhanglin Wu, Yuzhu Wang, Zhijun Li, Zhiwei Lin, Hanbin Ouyang, Bo Wei, Biru Liang, Yufeng He, Wenhua Huang

Abstract read
In one paragraph

Article in BMC musculoskeletal disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Zhanglin Wu *Orthopaedic Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Yuzhu Wang *Department of Orthopaedic Surgery, Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine, Zhongshan, Guangdong, China.
Zhijun Li *Department of Orthopaedics, The Fifth Affiliated Hospital of Southern Medical University, Guangzhou, China.
Zhiwei LinDepartment of Orthopaedics, The General Hospital of Western Theater Command, Chengdu, China.
Hanbin OuyangOrthopaedic Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Bo WeiOrthopaedic Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Biru LiangDepartment of Orthopaedics, The Fifth Affiliated Hospital of Southern Medical University, Guangzhou, China.
Yufeng HeDepartment of Traditional Treatment Center, Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine, 3, Kangxin Road, Xiqu District, Guangdong, Zhongshan, China. kfkhyf@163.com.
Wenhua HuangOrthopaedic Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China. hwh@smu.edu.cn.

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2020B1515120001National Key Research and Development Program of China 2022YFB4600600National Natural Science Foundation of China 21773199
6 · The paper itself

Abstract

backgroundAnterior cervical corpectomy and fusion (ACCF) is a crucial surgical procedure for addressing cervical degenerative diseases. However, traditional titanium mesh cages (TTMC) are susceptible to complications, such as cage subsidence and internal fixation failure. In this study, we developed a novel anatomic titanium mesh cage (NATMC) and assessed its biomechanical properties through finite element analysis.

methodsA conventional three-dimensional finite element model comprising cervical vertebrae C2–C7 was established using computed tomography (CT) data. Subsequently, two surgical models (TTMC and NATMC) were generated based on the normal model. Uniform load conditions were applied to these distinct surgical models to simulate flexion, extension, lateral bending, and axial rotation of the cervical spine. The range of motion (ROM), stress peaks at the titanium mesh-endplate interface, screw–bone interface, and the adjacent intervertebral disc were recorded and compared between the two groups.

resultsIn comparison to the intact model, the surgical segmental range of motion (ROM) for C4-6 was reduced by 96.89% in NATMC and 96.91% in TTMC. The stress peaks at the C4 inferior endplate and C6 superior endplate were higher in TTMC, measuring between 1.61 and 9.96 MPa and 1.46–14.29 MPa, respectively, followed by NATMC with values of 0.93–7.75 MPa and 1.08–11.69 MPa. Stress peaks on NATMC were lower (68.47–309.90 MPa) compared to TTMC (86.80–368.30 MPa). Regarding stress peaks at the screw-bone interface, NATMC exhibited lower values (11.91–42.49 MPa) compared to TTMC (35.49–153.00 MPa). Finally, comparing stress peaks in adjacent discs (C3/4 and C6/7), NATMC and TTMC showed similar results, ranging between 1.56 and 5.47 MPa in C3/4 and 1.56–2.91 MPa in C6/7, respectively.

conclusionsThe novel anatomic titanium mesh cage demonstrated effective reduction in vertebral subsidence and minimized pressure on the internal fixation interface following anterior cervical corpectomy and fusion (ACCF). It demonstrated superior stability and safety compared to traditional titanium mesh cage.

Indexed as

Cervical VertebraeFinite Element AnalysisInternal FixatorsSpinal FusionBiomechanical PhenomenaHumansModels, AnatomicRange of Motion, ArticularSurgical MeshTitaniumTomography, X-Ray ComputedTitaniumAnterior cervical corpectomyFinite element analysisNovel anatomic fusion cage

Identifiers

PMID41965598
PMCPMC13192124

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.