ArticleBMC pediatrics2026
Heavy metal exposure and dental caries in children and adolescents: a NHANES-based analysis integrating machine learning approaches.
Article in BMC pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundDental caries remains a major public health concern among children and adolescents. While established risk factors such as diet and oral hygiene are well recognized, the association between environmental heavy metal exposure and pediatric dental caries is not fully understood. This study examined the relationship between blood heavy metal concentrations and dental caries in a nationally representative pediatric population.
methodsData from 15,194 participants aged 5-19 years were obtained from the National Health and Nutrition Examination Survey (NHANES). Dental caries was assessed using the DMFT/S index. Blood lead, cadmium, and mercury concentrations were measured by inductively coupled plasma mass spectrometry. Multivariable logistic regression models were used to evaluate associations after adjustment for sociodemographic, nutritional, and hematological covariates. Multiple machine learning models were constructed to assess predictive performance, and SHAP values were applied to interpret feature importance.
resultsHigher blood concentrations of lead, cadmium, and mercury were independently associated with increased odds of dental caries (lead: OR = 1.10, 95% CI: 1.02-1.18; cadmium: OR = 1.18, 95% CI: 1.10-1.27; mercury: OR = 1.14, 95% CI: 1.06-1.22). Subgroup analyses demonstrated heterogeneity by age and socioeconomic status, with stronger associations for cadmium observed among adolescents and higher-income groups. Among the machine learning models, XGBoost showed the best predictive performance (AUC = 0.75), with cadmium ranking as the most influential feature.
conclusionBlood heavy metal concentrations were significantly associated with dental caries in children and adolescents, suggesting that environmental exposure may be an important correlate of pediatric caries risk.
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