Evidence map›Paper›PMID 41965519›Full record

ArticleBMC genomics2026

Novel candidate genes for vestibular function identified through GWAS in the hybrid mouse diversity panel.

Yuzuru Ninoyu, Calvin Pan, Jennifer Luu, Sameeha Rashid, Jadyn Johnston, Briana Ortega, Ely Boussaty, Lu Lu, Royce Clifford, Pejman Mohammadi and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yuzuru NinoyuDepartment of Otolaryngology - Head and Neck Surgery, University of California San Diego, La Jolla, CA, USA.
Calvin PanDepartment of Medicine, Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Jennifer LuuDepartment of Otolaryngology - Head and Neck Surgery, University of California San Diego, La Jolla, CA, USA.
Sameeha RashidDepartment of Otolaryngology - Head and Neck Surgery, University of California San Diego, La Jolla, CA, USA.
Jadyn JohnstonDepartment of Otolaryngology - Head and Neck Surgery, University of California San Diego, La Jolla, CA, USA.
Briana OrtegaDepartment of Otolaryngology - Head and Neck Surgery, University of California San Diego, La Jolla, CA, USA.
Ely BoussatyDepartment of Otolaryngology - Head and Neck Surgery, University of California San Diego, La Jolla, CA, USA.
Lu LuDepartment of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN, USA.
Royce CliffordDepartment of Otolaryngology - Head and Neck Surgery, University of California San Diego, La Jolla, CA, USA.
Pejman MohammadiCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, USA.
Francesca TeleseDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Abraham A PalmerDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Aldons J LusisDepartment of Medicine, Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Rick A FriedmanDepartment of Otolaryngology - Head and Neck Surgery, University of California San Diego, La Jolla, CA, USA. rafriedman@health.ucsd.edu.

Funding

The genetics of functional decline in the aging vestibular system: A GWAS and gene expression analysis in aging mice and humansR01DC020052 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CLIFFORD, ROYCE ELLEN, FRIEDMAN, RICK A · 2021 to 2025
$4.0M
Foundation for the National Institutes of Health R01-020052Japan Society for the Promotion of Science JP 24K12724NIDCD NIH HHS R01 DC020052
6 · The paper itself

Abstract

Disequilibrium is a highly prevalent age-related condition that increases fall risk, yet the genetic architecture underlying vestibular function remains poorly defined. Here, we performed genome-wide association studies (GWAS) of vestibular-evoked potentials (VsEP) and raised-beam performance across young and aged Hybrid Mouse Diversity Panel (HMDP) strains. In young mice, we identified genome-wide significant loci on chromosomes 4, 7, 14, and 15, along with suggestive associations on chromosomes 6 and 14. To refine candidate genes, we integrated cochlear and cerebellar cis-eQTL data from BXD strains with human cochlear transcriptomic profiles, revealing 12 cochlea-enriched genes within linkage disequilibrium intervals. Single-cell RNA sequencing localized Agbl4, Cntnap2, Dmc1, and Pcdh20 to vestibular hair cells, and Gpnmb to melanocytes of the inner ear. These findings highlight coordinated contributions of sensory and non-sensory cell types to vestibular performance. Although no significant loci were detected in aged mice, our integrative genetic and transcriptomic framework provides new insight into the molecular architecture of vestibular function and potential pathways underlying age-related balance impairment.

Indexed as

Genome-Wide Association StudyVestibule, LabyrinthAnimalsCochleaGene Expression ProfilingHumansLinkage DisequilibriumMicePolymorphism, Single NucleotideQuantitative Trait LociTranscriptomeCochleaGenome-wide association studies (GWAS)vestibular function

Identifiers

PMID41965519
PMCPMC13182000

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.