Evidence map›Paper›PMID 41965467›Full record

ArticleJournal of patient-reported outcomes2026

Associations between ischaemic stroke subtypes and physical functioning in the first year post-stroke: a patient-reported outcome study.

Tim Hagleitner, Dennis Freuer, Michael Ertl, Markus Naumann, Jakob Linseisen, Christa Meisinger

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Article in Journal of patient-reported outcomes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Tim HagleitnerEpidemiology, Medical Faculty, University of Augsburg, 86156, Augsburg, Germany.
Dennis FreuerEpidemiology, Medical Faculty, University of Augsburg, 86156, Augsburg, Germany.
Michael ErtlDepartment of Neurolgy and Neurological Rehabilitation, District Hospital Guenzburg, 89312, Guenzburg, Germany.
Markus NaumannDepartment of Neurology and Clinical Neurophysiology, University Hospital Augsburg: Universitatsklinikum Augsburg, 86156, Augsburg, Germany.
Jakob LinseisenEpidemiology, Medical Faculty, University of Augsburg, 86156, Augsburg, Germany.
Christa MeisingerEpidemiology, Medical Faculty, University of Augsburg, 86156, Augsburg, Germany. christine.meisinger@med.uni-augsburg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIschaemic stroke etiology, as defined by the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification, has been associated with differences in survival and functional outcomes when assessed using the modified Rankin Scale (mRS). This study investigated whether similar patterns are reflected in patient-reported physical functioning during the first year post-stroke.

methodsWe analysed data from the Stroke Cohort Augsburg (SCHANA), a prospective study of adults with confirmed ischaemic stroke treated at a tertiary care hospital in Southern Germany between 2018 and 2022. Physical functioning was assessed at 3- and 12-month post-discharge by using the physical domain score of the Stroke Impact Scale (SIS). Associations with stroke etiology were examined using linear mixed-effects models to improve precision and account for variable follow-up availability.

resultsThe final analytic sample included 1,044 patients and was characterised by predominantly mild neurological impairment at admission (median NIHSS 2.0). In adjusted linear mixed-effects models, stroke etiology was not significantly associated with patient-reported physical functioning. No etiologic subgroup differed significantly from the cardioembolic reference group (all p > 0.05).

conclusionsAmong patients with predominantly mild ischaemic stroke, patient-reported physical functioning varied little across TOAST-defined subtypes. This may reflect limited between-group variation in stroke severity at baseline and conceptual differences between patient-reported and clinician-assessed outcome measures such as the mRS.

Indexed as

Ischemic StrokePatient Reported Outcome MeasuresPhysical Functional PerformanceStrokeAgedAged, 80 and overFemaleGermanyHumansMaleMiddle AgedProspective StudiesRecovery of FunctionSeverity of Illness IndexActivities of daily livingEtiologyIschaemic strokeMotor activityPatient reported outcome measuresQuality of life

Identifiers

PMID41965467
PMCPMC13083565

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.