ArticleStem cell reviews and reports2026
Molecular and Cellular Analysis of Lipogems-Processed Lipoaspirates for Evaluating the Efficacy of Treatments in Regenerative Medicine.
Article in Stem cell reviews and reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Autologous adipose tissue is a readily available source of mesenchymal stromal cells (MSCs) for regenerative applications. Here, human lipoaspirates from eight donors processed with the Lipogems system were characterized by flow cytometry (MSC/pericyte markers and inflammatory markers), immunocytochemistry (NANOG, OCT3/4, SOX2), and functional assays assessing proliferation, senescence, apoptosis, multilineage differentiation, IDO activity, and ROS levels. Lipogems-derived cultures fulfilled MSC immunophenotypic criteria while showing marked inter-donor variability in MSC/pericyte proportions, stemness-marker expression, differentiation bias, inflammatory profile, and oxidative status. In contrast, senescence and apoptosis were comparable across samples. Clinical evaluation, based on surgeon-assessed outcomes after autologous treatment, scored on a 1–10 scale, was consistently high across donors (7–10). Overall, Lipogems-processed lipoaspirates harbor a heterogeneous but functionally competent stromal compartment; these data support a sample-specific quality framework (composition, differentiation tendency, inflammation/ROS, IDO responsiveness) to improve reproducibility and optimization of regenerative protocols.
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