Evidence map›Paper›PMID 41964785›Full record

ArticleJournal of endocrinological investigation2026

Higher osteocalcin levels are associated with preserved β-cell function in early-established type 1 diabetes.

Tingting Zhuang, Qixiang Yang, Donghui Yang, Lei Qian, Yan Bi, Jing Lu

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Article in Journal of endocrinological investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tingting Zhuang *Department of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, Jiangsu Province, China.
Qixiang Yang *Department of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, Jiangsu Province, China.
Donghui YangDepartment of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, 321 Zhongshan Road, Gulou District, Nanjing, 210008, Jiangsu Province, China.
Lei QianDepartment of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, 321 Zhongshan Road, Gulou District, Nanjing, 210008, Jiangsu Province, China.
Yan BiDepartment of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, Jiangsu Province, China. Biyan@nju.edu.cn.ORCID http://orcid.org/0000-0003-3914-7854
Jing LuDepartment of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, 321 Zhongshan Road, Gulou District, Nanjing, 210008, Jiangsu Province, China. lujingsnow@126.com.ORCID http://orcid.org/0000-0002-9496-5182

Funding

Clinical Trials from the Affiliated Drum Tower Hospital 2021-LCYJ-PY-10Noncommunicable Chronic Diseases-National Science and Technology Major Project 2023ZD0509100the National Natural Science Foundation of China Grant Award 82270887
6 · The paper itself

Abstract

purposeBone-derived cytokines have been implicated in glucose metabolism, but their role in type 1 diabetes mellitus (T1DM) is unclear. We investigated alterations in bone turnover markers (BTMs) and their associations with β-cell function and autoimmunity in T1DM.

methodsThis cross-sectional study enrolled 369 T1DM individuals and 150 matched controls. Serum BTMs, fasting C-peptide (FCP), HbA1c, glucose, and islet-autoimmune profile were measured. Analyses included group comparisons, linear regression, and Locally Estimated Scatterplot Smoothing (LOESS) to visualize the relationships of FCP and osteocalcin (OC) with disease duration. A logistic-regression model incorporating OC was developed to assess β-cell failure in participants at early stage of established T1DM.

resultsSerum BTMs were significantly lower in T1DM versus controls, and lowest in the low-FCP subgroup. Only log

conclusionIn early-established T1DM, OC independently associates with preserved β-cell function. Higher OC levels were accompanied by better β-cell function and an expanded regulatory T-cell pool, suggesting a potential role in the islet immune microenvironment.

Indexed as

BiomarkersDiabetes Mellitus, Type 1Insulin-Secreting CellsOsteocalcinAdultBlood GlucoseBone RemodelingCase-Control StudiesC-PeptideCross-Sectional StudiesFemaleGlycated HemoglobinHumansMaleBiomarkersBlood GlucoseC-PeptideGlycated HemoglobinOsteocalcinAutoimmunityBone turnover markersOsteocalcinPancreatic β-cell functionRegulatory T cellsType 1 diabetes mellitus

Identifiers

PMID41964785

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.