Evidence map›Paper›PMID 41964749›Full record

ArticleMolecular and cellular biochemistry2026

Regulation of EMT and cholangiocarcinoma metastasis by KIN17 through the mTOR signaling pathway.

Yuxia Yang, Qianying Luo, Chuhong Huang, Xiaocong Lin, Lok Ting Chu, Qiuyan Li, Jinjing Tang, Tao Zeng

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Article in Molecular and cellular biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuxia Yang *Department of Medical Laboratory, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524000, Guangdong, P. R. China.
Qianying Luo *Department of Medical Laboratory, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524000, Guangdong, P. R. China.
Chuhong Huang *Department of Medical Laboratory, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524000, Guangdong, P. R. China.
Xiaocong Lin *Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Guangdong Medical University, Zhanjiang, 524023, Guangdong, P. R. China.
Lok Ting Chu *Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Guangdong Medical University, Zhanjiang, 524023, Guangdong, P. R. China.
Qiuyan Li *Department of Medical Laboratory, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524000, Guangdong, P. R. China.
Jinjing Tang *Department of Medical Laboratory, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524000, Guangdong, P. R. China.
Tao ZengDepartment of Medical Laboratory, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524000, Guangdong, P. R. China. zengt@smu.edu.cn.

Funding

Medical Science and Technology Research Project of Guangdong Province No. B2021180Start-up Fund for High-level Talents in Affiliated Hospital of Guangdong Medical University No. 51301Z20200007This work was supported by the Guangdong Basic and Applied Basic Research Foundation No. 2023A1515010235 and 2025A1515011140
6 · The paper itself

Abstract

KIN17 is a DNA- and RNA-binding protein involved in the regulation of several human cancers. However, its role in cancer progression and metastasis in cholangiocarcinoma remains largely unknown. In this work, the expression of KIN17 in CCA patients was investigated using bioinformatics and immunohistochemical staining. The effects of KIN17 on CCA cells’ migration and invasion were examined by scratch assay and transwell assay. In RBE and HCCC-9810 cells, knockdown of KIN17 significantly suppressed the migration and invasion ability of the cells and also inhibited the mTOR pathway, while overexpression of KIN17 promoted the migration and invasion ability of HUCCT-1 cells and stimulated the mTOR pathway, as well as genes involved in epithelial-mesenchymal transition. These findings indicate that expression of KIN17 in CCA is abnormal compared to the normal conditions and promotes the invasion and migration of CCA cells. Meanwhile, we hypothesize that KIN17 affects the migration and invasion of CCA cells through the regulation of mTOR and EMT signaling pathways. Hence, we propose KIN17 to be a novel diagnostic biomarker and therapeutic target for CCA.

Indexed as

Bile Duct NeoplasmsCholangiocarcinomaEpithelial-Mesenchymal TransitionNeoplasm ProteinsRNA-Binding ProteinsSignal TransductionTOR Serine-Threonine KinasesCell Line, TumorCell MovementGene Expression Regulation, NeoplasticHumansNeoplasm InvasivenessNeoplasm MetastasisMTOR protein, humanNeoplasm ProteinsRNA-Binding ProteinsTOR Serine-Threonine KinasescholangiocarcinomaEMTinvasionKIN17migrationmTOR

Identifiers

PMID41964749

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.