Evidence map›Paper›PMID 41964735›Full record

ArticleJournal of neurology2026

Weight maintenance following enteral nutrition is associated with prolonged survival in amyotrophic lateral sclerosis.

Chiharu Matsuda, Yuki Nakayama, Michiko Haraguchi, Ryo Morishima, Yumi Itagaki, Kota Bokuda, Kentaro Hayashi, Kazushi Takahashi, Toshio Shimizu

Abstract read
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In one paragraph

Article in Journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chiharu MatsudaUnit for Intractable Disease Nursing Care, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya, Tokyo, 156-8506, Japan.ORCID http://orcid.org/0000-0001-9209-6094
Yuki NakayamaUnit for Intractable Disease Nursing Care, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya, Tokyo, 156-8506, Japan. nakayama-yk@igakuken.or.jp.ORCID http://orcid.org/0000-0001-8620-612X
Michiko HaraguchiUnit for Intractable Disease Nursing Care, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya, Tokyo, 156-8506, Japan.ORCID http://orcid.org/0009-0002-8520-4338
Ryo MorishimaDepartment of Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.ORCID http://orcid.org/0000-0003-0774-2827
Yumi ItagakiUnit for Intractable Disease Nursing Care, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya, Tokyo, 156-8506, Japan.ORCID http://orcid.org/0000-0002-1439-0017
Kota BokudaDepartment of Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.ORCID http://orcid.org/0000-0002-8577-6654
Kentaro HayashiDepartment of Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.ORCID http://orcid.org/0000-0001-7124-7658
Kazushi TakahashiDepartment of Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.ORCID http://orcid.org/0000-0003-2904-6080
Toshio ShimizuUnit for Intractable Disease Nursing Care, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya, Tokyo, 156-8506, Japan.ORCID http://orcid.org/0000-0002-3828-9669

Funding

Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research [B] No. 23K24656Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research[C] No. 23K09948
6 · The paper itself

Abstract

objectiveTo investigate the association between energy intake at the initiation of enteral nutrition (EN), subsequent changes in body mass index (BMI), and survival in patients with amyotrophic lateral sclerosis (ALS).

methodsThis retrospective study included 121 patients with ALS who received EN. Annual BMI decline rates (∆BMI, kg/m

resultsPost-EN BMI decline (∆BMI

conclusionWeight maintenance following EN was associated with prolonged survival in ALS, whereas energy intake at EN initiation alone was not. These findings suggest that the survival benefit of nutritional intervention may be mediated through stabilization of body weight rather than caloric intake per se.

Indexed as

Amyotrophic Lateral SclerosisBody WeightEnergy IntakeEnteral NutritionAgedBody Mass IndexFemaleHumansKaplan-Meier EstimateMaleMiddle AgedProportional Hazards ModelsRetrospective StudiesAmyotrophic lateral sclerosisBody mass indexEnergy intakeEnteral nutritionSurvival

Identifiers

PMID41964735

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.