ArticleJournal of veterinary internal medicine2026
Prognostic value of plasma cortisol concentration in dogs with congestive heart failure.
Article in Journal of veterinary internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundThe association of plasma cortisol concentration with prognosis for dogs with congestive heart failure (CHF) is unknown. HYPOTHESIS/
objectivesTo determine whether higher plasma cortisol concentration was independently associated with greater risk of cardiac mortality in dogs with CHF. Additional study aims were to evaluate the associations between other clinical, neurohormonal, and echocardiographic indices and cardiac mortality. ANIMALS: Thirty-one client-owned dogs with CHF secondary to myxomatous mitral valve disease (MMVD).
methodsProspective cohort observational study. Plasma cortisol measurement, urine cortisol-to-creatinine ratio, renal function test results, serum electrolytes, biomarkers of the renin-angiotensin-aldosterone system, N-terminal pro-B-type natriuretic peptide, and echocardiography were performed in dogs with MMVD at first onset of CHF. Plasma cortisol was repeated 7-14 days later. Association between plasma cortisol and other covariates with survival was determined using a proportional hazards regression model.
resultsPlasma cortisol concentration was not associated with cardiac (P = .112; hazard ratio [HR] 1.01; 95% CI, 0.998-1.02) or all-cause mortality (P = .143; HR 1.01; 95% CI, 0.998-1.02). Treatment with angiotensin-converting enzyme inhibitors (P = .021; HR 0.058; 95% CI, 0.0052-0.66) was associated with longer survival to cardiac mortality. Treatment with spironolactone (P = .038; HR 0.36; 95% CI, 0.14-0.94), percent fractional shortening (P = .034; HR 0.0018; 95% CI, 5.44 × 10-6 to 0.61), and lower serum potassium (P = .048; HR 2.07; 95% CI, 1.01-4.27) at diagnosis were associated with longer survival to all-cause mortality. Spironolactone treatment at baseline was associated with all-cause mortality on multivariable regression analysis. CONCLUSIONS AND CLINICAL IMPORTANCE: Plasma cortisol concentrations were not associated with cardiac mortality in this sample of dogs with CHF.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.