Evidence map›Paper›PMID 41964591›Full record

SynthesisMedical gas research2026

Mechanism and clinical application of ozone therapy in treating skin ulcer diseases.

Yizhi Pan, Baoxiang Wang, Xuyuan Kuang

Abstract readSystematic Review
In one paragraph

Synthesis in Medical gas research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yizhi PanDepartment of Dermatology, The Third Xiangya Hospital of Central South University, Changsha, Hunan Province, China.ORCID 0009-0008-5129-3698
Baoxiang WangHealth Management Center, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Xuyuan KuangDepartment of Hyperbaric Oxygen, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ozone therapy not only has antibacterial effects but also has a series of biological effects. It can stimulate the production of antioxidant enzymes, increase the elasticity of red blood cell membranes, improve blood flow and tissue oxygenation, promote the release of growth factors, and activate cell metabolism and immune function. Through multi-target regulation, ozone therapy has shown significant efficacy in treating skin ulcer diseases such as diabetic foot ulcers and burns, with overall controllable safety. Currently, most research on ozone therapy focuses on the correlation between the ozone concentration and therapeutic efficacy. This review provides a systematic review of the mechanism and clinical research progress of ozone therapy in treating skin ulcer diseases. While ozone therapy has demonstrated notable effectiveness in treating diabetic foot ulcers and other conditions, more rigorous clinical research is necessary to refine treatment plans and create standard guidelines for its use. In the future, the integration of ozone therapy with precision medicine and innovative delivery methods could broaden its application in treating skin ulcer diseases.

Indexed as

OzoneSkin UlcerAnimalsDiabetic FootHumansWound HealingOzoneangiogenesisantimicrobialdiabetic foot ulcersozone gas bathozone hydrogelozone therapypain modulationre-epithelializationskin ulcer diseasetopical oxygen therapy

Identifiers

PMID41964591
PMCPMC13456378

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.