Evidence map›Paper›PMID 41964438›Full record

ArticleJournal of medical virology2026

HIV-1 Non Group-M Phenotypic Susceptibility to Ibalizumab.

Lucie Poisson, Quentin Le Hingrat, Fanny Lermechain, Fabienne Tombette, Henri Jullien, Jean-Christophe Plantier, Elodie Alessandri-Gradt

Abstract read
In one paragraph

Article in Journal of medical virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lucie PoissonLaboratoire de Virologie, CHU de Rouen, Rouen, France.ORCID https://orcid.org/0009-0009-5794-2131
Quentin Le HingratUniversité Paris Cité, INSERM UMR1137, IAME, Paris, France.
Fanny LermechainLaboratoire de Virologie, CHU de Rouen, Rouen, France.
Fabienne TombetteLaboratoire de Virologie, CHU de Rouen, Rouen, France.
Henri JullienTheratechnologies Inc., Montreal, Quebec, Canada.
Jean-Christophe PlantierDYNAMICURE UMR1311, CHU Rouen, Département de Virologie, UnivRouen Normandie, Université de Caen Normandie, INSERM, Normandie University, Rouen, France.
Elodie Alessandri-GradtLaboratoire de Virologie, CHU de Rouen, Rouen, France.ORCID https://orcid.org/0000-0002-8906-3416

Funding

Santé Publique France
6 · The paper itself

Abstract

The study assessed the phenotypic susceptibility of non group-M human immunodeficiency virus type 1 (HIV-1/non-M) clinical isolates to ibalizumab, the first-in-class long-acting CD4-directed post-attachment inhibitor. Thirty isolates were tested: 1 HIV-1/M (reference strain BRU.HXB2), 2 HIV-1/N, 26 HIV-1/O and 1 HIV-1/P. A phenotypic in vitro assay was performed by pre-incubating peripheral blood mononuclear cells with ibalizumab, (1-10 000 ng/mL), then infected and incubated before quantifying viral load with RT-PCR. IC

Indexed as

Antibodies, MonoclonalAnti-HIV AgentsHIV-1GlycosylationHIV InfectionsHumansInhibitory Concentration 50Leukocytes, MononuclearMicrobial Sensitivity TestsPhenotypeViral LoadAntibodies, MonoclonalAnti-HIV Agentsibalizumabanti‐retrovirus drugentry inhibitorsgenetic variabilityHIVresistance

Identifiers

PMID41964438
PMCPMC13069599

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.