Evidence map›Paper›PMID 41964364›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2026

The role of dopamine decline, astrocyte reactivity and cerebral small-vessel disease in cognitive aging.

Vanessa Crine, Jarkko Johansson, Olivia Ericsson, Anders Wåhlin, Jan Axelsson, Micael Anderssson, Lars Nyberg, Nina Karalija

Abstract read
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In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Imaging the interaction of astrocytes and neurons.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vanessa CrineDepartment of Medical and Translational Biology, Umeå University, Umeå, Sweden.
Jarkko JohanssonUmeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden.
Olivia EricssonDepartment of Medical and Translational Biology, Umeå University, Umeå, Sweden.
Anders WåhlinUmeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden.
Jan AxelssonDepartment of Diagnostics and Intervention, Umeå University, Umeå, Sweden.ORCID 0000-0002-3731-3612
Micael AndersssonDepartment of Medical and Translational Biology, Umeå University, Umeå, Sweden.
Lars NybergDepartment of Medical and Translational Biology, Umeå University, Umeå, Sweden.
Nina KaralijaDepartment of Medical and Translational Biology, Umeå University, Umeå, Sweden.ORCID 0000-0002-8603-9453

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several aging-related brain changes have been associated with unsuccessful cognitive aging, including dopamine decline, increased astrocyte reactivity, and cerebral small-vessel disease (SVD). We hypothesized that dopamine decline is exacerbated in older adults with higher measures of astrocyte reactivity and cerebral SVD, and that reduced dopamine integrity would be the strongest predictor of lower cognitive performance. Healthy adults (

Indexed as

AstrocytesCerebral Small Vessel DiseasesCognitive AgingDopamineAgedAgingCognitionDopamine Plasma Membrane Transport ProteinsDopaminergic ImagingFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMonoamine OxidasePositron-Emission TomographyDopamineDopamine Plasma Membrane Transport ProteinsMonoamine Oxidase11C-L-deprenyl-D218F-FE-PE2Icerebral small-vessel diseasecognitionpositron emission tomography

Identifiers

PMID41964364
PMCPMC13070112

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.