ArticleAnnals of Indian Academy of Neurology2026
Spontaneous Intracranial Hypotension: A Tertiary Care Experience.
Article in Annals of Indian Academy of Neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesSpontaneous intracranial hypotension (SIH) is a rare, often underdiagnosed cause of secondary headache resulting from spontaneous cerebrospinal fluid leakage. Indian data on its clinical profile and treatment outcomes remain limited. We aimed to describe the clinical, radiological, and treatment characteristics of patients with SIH at a tertiary neurology centre in South India and to compare outcomes between those treated with epidural blood patch (EBP) and conservative management.
methodsThis retrospective observational study included 33 patients fulfilling the International Classification of Headache Disorders - 3 (ICHD-3) diagnostic criteria for SIH between 2004 and 2024. Clinical features, magnetic resonance imaging (MRI) findings, treatment modalities, and outcomes were analyzed. Statistical comparisons were performed using Chi-square or t tests, with P < 0.05 considered significant.
resultsOf the 33 patients (73% female; mean age, 42 ± 11 years), orthostatic headache was present in 91%. Pachymeningeal enhancement was the most common MRI finding (90%), followed by pituitary engorgement (59%) and spinal epidural fluid collections (52%). Twenty patients (61%) received EBP, and thirteen (39%) were managed conservatively. EBP led to significantly higher rates of headache resolution at discharge (80% vs. 31%, P = 0.005), although long-term outcomes at 3 months were comparable (75% vs. 62%, P = 0.5). Procedure-related complications were mild and transient.
conclusionsThis study represents the largest Indian SIH series to date, highlighting the predominance of orthostatic headache and pachymeningeal enhancement. EBP offers rapid symptomatic relief and remains the preferred initial therapy. Early recognition and standardized imaging protocols are vital for improved outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.