Evidence map›Paper›PMID 41964114›Full record

ArticleNeurogastroenterology and motility2026

Resting and Squeeze Anal Pull-Through Assessments by Fecobionics Demonstrate Weak Anal Sphincters in Patients With Fecal Incontinence.

Giuliana Barron Del Solar, Xiaomei Guo, Danielle Long, Yun Yan, Abeer Aziz, Delaram Asadi, Karlo Fidel, Satish S C Rao, Hans Gregersen

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PubMed Full text at PMC Publisher
In one paragraph

Article in Neurogastroenterology and motility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Giuliana Barron Del SolarCalifornia Medical Innovations Institute, San Diego, California, USA.
Xiaomei GuoCalifornia Medical Innovations Institute, San Diego, California, USA.
Danielle LongJ. WellStar MCG Health Augusta University, Augusta, Georgia, USA.
Yun YanJ. WellStar MCG Health Augusta University, Augusta, Georgia, USA.
Abeer AzizJ. WellStar MCG Health Augusta University, Augusta, Georgia, USA.
Delaram AsadiJ. WellStar MCG Health Augusta University, Augusta, Georgia, USA.
Karlo FidelJ. WellStar MCG Health Augusta University, Augusta, Georgia, USA.ORCID https://orcid.org/0000-0001-7345-0107
Satish S C RaoJ. WellStar MCG Health Augusta University, Augusta, Georgia, USA.
Hans GregersenCalifornia Medical Innovations Institute, San Diego, California, USA.ORCID https://orcid.org/0000-0002-5792-2845

Funding

Pathophysiology, diagnosis and biofeedback therapy in fecal incontinence using fecobionicsR01DK131488 · NIDDK · CALIFORNIA MEDICAL INNOVATIONS INSTITUTE · PI Hans Gregersen, Satish SC Rao · 2022 to 2026
$3.2M
Defecation mechanisms and subtyping of constipation patients with FecobionicsR01DK125657 · NIDDK · CALIFORNIA MEDICAL INNOVATIONS INSTITUTE · PI GREGERSEN, HANS · 2021 to 2025
$3.0M
Fecobionics monitoring and prediction of biofeedback therapy outcome in patients with obstructed defecation.R01DK134689 · NIDDK · CALIFORNIA MEDICAL INNOVATIONS INSTITUTE · PI GREGERSEN, HANS, KASSAB, GHASSAN S · 2023 to 2025
$1.1M
NIDDK NIH HHS R01 DK125657NIDDK NIH HHS R01 DK131488NIDDK NIH HHS R01 DK134689NIH HHS R01DK125657NIH HHS R01DK131488NIH HHS R01DK134689
6 · The paper itself

Abstract

backgroundMany fecal incontinence (FI) patients have low anal sphincter pressure, which is thought to be a major pathophysiological mechanism. This is assessed either by stationary or pull-through manometry techniques. Fecobionics is a new device for comprehensive assessment of anorectal function.

aimTo evaluate anal pressure profiles during rest and squeeze pull-through maneuvers in FI patients and normal subjects (NS) using Fecobionics and to compare with current technology.

methodsPatients with FI (Rome IV criteria) and healthy controls were recruited. FI severity was assessed with FISI questionnaire. Anal pull-through maneuvers were performed using Fecobionics and anorectal manometry (ARM) during rest and maximum anal squeeze, and the pull-through pressures were measured and compared. Data were expressed as median and quartiles. Non-parametric statistical testing was done.

resultsForty-four FI patients and 20 NS participated. The FISI score was 0 (0-0) in the NS group and 28 (22-35) in the FI group. Resting pull-through pressure did not differ between FI patients (82.0 (56.0-145.5 cmH

conclusionsFecobionics device showed lower squeeze pressures in FI patients compared to NS during anal pull-through procedure and strong associations between these pressures and FI subgroups.

Indexed as

Anal CanalFecal IncontinenceManometryAdultAgedFemaleHumansMaleMiddle AgedPressureRestanorectalanorectal manometrydefecationfecal incontinenceFecobionicspull‐through

Identifiers

PMID41964114
PMCPMC13157201

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.