ArticleBiomarker research2026
Outcomes of patients with CLL and borderline IGHV mutational status: a systematic review and meta analysis.
Article in Biomarker research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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13 authors.
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Abstract
The immunoglobulin heavy chain variable region (IGHV) mutational status is a major prognostic factor in chronic lymphocytic leukemia (CLL). While patients are conventionally classified as mutated (M-IGHV) or unmutated (U-IGHV) using a 98% germline identity cutoff, increasing interest has focused on patients with IGHV identity values close to this threshold, defined as having a borderline IGHV mutational status (BL-IGHV) whose clinical significance remains controversial. We conducted a systematic review and meta-analysis to clarify the prognostic impact of BL-IGHV in CLL. Following PRISMA guidelines, we identified studies comparing time to first treatment (TTFT) in BL-IGHV patients with M-IGHV and U-IGHV cohorts. A secondary endpoint was the prevalence of B-cell receptor (BCR) stereotyped subset #2. Overall, 122 BL-IGHV patients from 3 studies were included. BL-IGHV patients exhibited a significantly shorter TTFT compared with M-IGHV patients (HR 2.28; 95% CI 1.20–4.35), and a non-significant trend toward longer TTFT compared with U-IGHV patients. Median TTFT for BL-IGHV was intermediate between M-IGHV and U-IGHV groups, and BL-IGHV cases were markedly enriched for BCR stereotyped subset #2. In conclusion, BL-IGHV identifies a clinically and biologically distinct CLL subgroup with intermediate outcomes, supporting its systematic reporting and potential relevance for risk stratification.
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