Evidence map›Paper›PMID 41964042›Full record

ReviewJournal of anesthesia, analgesia and critical care2026

Prediction of spinal anesthesia-induced hypotension during cesarean delivery: a narrative review.

Mina Adolf Helmy, Kerlous Adolf Helmy, Wael Mahmoud El Darandly, Haitham Hassan Awad, Fatma Morsy, Reham Amin Kaddah, Mohamed Ahmed Shamma, Lydia Magdy Milad

Registry-linked trialAbstract readReview
In one paragraph

Review in Journal of anesthesia, analgesia and critical care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07655245 (Effect of Preoperative Oral Caffeine on Prophylactic Noradrenaline Requirement During Cesarean Delivery), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07655245 nanot yet recruitingnot on this map

Effect of Preoperative Oral Caffeine on Prophylactic Noradrenaline Requirement During Cesarean Delivery: A Double-blind Placebo-controlled Trial

TypeinterventionalSponsorCairo UniversityRan2026 to 2026Enrolled62ConditionsSpinal Hypotension, VasopressorArmsCaffeine (200 mg), Placebo
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mina Adolf HelmyDepartment of Anesthesia and Critical Care Medicine, Cairo University, Cairo, Egypt. dr_mina20002010@yahoo.com.ORCID http://orcid.org/0009-0006-2831-1443
Kerlous Adolf HelmyDepartment of Obstetrics, Gynecology and Perinatology, Sechenov University, Moscow, Russia.
Wael Mahmoud El DarandlyDepartment of Anesthesia and Critical Care Medicine, Mataryah Teaching Hospital, Cairo, Egypt.
Haitham Hassan AwadDepartment of Anesthesia and Critical Care Medicine, Cairo University, Cairo, Egypt.
Fatma MorsyDepartment of Anesthesia and Critical Care Medicine, Cairo University, Cairo, Egypt.
Reham Amin KaddahDepartment of Anesthesia and Critical Care Medicine, Cairo University, Cairo, Egypt.
Mohamed Ahmed ShammaDepartment of Anesthesia and Critical Care Medicine, Cairo University, Cairo, Egypt.
Lydia Magdy MiladDepartment of Anesthesia and Critical Care Medicine, Cairo University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal anesthesia-induced hypotension remains a major challenge in obstetric anesthesia, with significant maternal and fetal consequences despite prophylactic measures. Reliable prediction tools are essential to stratify risk and optimize management. This review narratively discusses evidence on clinical, hemodynamic, Doppler-derived, and pulse oximetry-based predictors of spinal anesthesia-induced hypotension in cesarean delivery. Clinical factors such as body mass index, maternal age, baseline blood pressure, and spinal anesthetic dose demonstrate variable predictive value. Hemodynamic markers, including heart rate variability and shock index, show promise but require further validation. Advanced monitoring techniques, such as stroke volume variation, subaortic velocity time integral, and femoral artery Doppler indices, exhibit high accuracy, while venous diameter-based measures (inferior vena cava, internal jugular vein, subclavian vein-axillary vein) yield inconsistent results. Pulse oximetry-derived indices, particularly the perfusion index, demonstrate moderate to good predictive ability across systematic reviews. Composite risk models integrating multiple parameters may enhance precision compared to single predictors. Overall, while several modalities show potential, translation into routine practice requires simplification, validation in larger cohorts, and integration into standard monitoring systems.

Indexed as

Doppler indicesSpinal anesthesia-induced hypotensionVelocity time integral

Identifiers

PMID41964042
PMCPMC13072510

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.