Evidence map›Paper›PMID 41964037›Full record

ArticleBiological research2026

OGDH mediates α-ketoglutarate-induced follicular development and antioxidative response by interacting with CAT/SOD2.

Enyuan Huang, Jingyu Zhou, Mengting Hu, Liuhong Zhang, Jiahao Shao, Meng Lv, Fen Miao, Yao Jiang, Nian Li, Jiaqi Li and 1 more

Abstract read
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In one paragraph

Article in Biological research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Enyuan HuangState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Jingyu ZhouState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Mengting HuState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Liuhong ZhangState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Jiahao ShaoState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Meng LvState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Fen MiaoState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Yao JiangState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Nian LiState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Jiaqi LiState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Xiaolong YuanState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, 510642, Guangdong, China. yxl@scau.edu.cn.ORCID http://orcid.org/0000-0002-3743-0130

Funding

Earmarked Fund for China Agriculture Research System CARS-35Guangdong Basic and Applied Basic Research Foundation 2023A1515030054Guangdong Basic and Applied Basic Research Foundation 2024A1515012999Guangdong Basic and Applied Basic Research Foundation 2024B1515020112Morden Agricultural Industrial Technology System Innovation Team of Guangdong Province 2024CXTD22National Center of Technology Innovation for Pigs NCTIP-XDB14National Natural Science Foundation of China 32072694Science and Technology Project of Guangzhou 2024B03J1305
6 · The paper itself

Abstract

backgroundFollicular disorders, often driven by ROS-induced granulosa cell apoptosis, are a major cause of female infertility. While α-ketoglutarate (AKG), also known as 2-oxoglutarate, can improve follicular development, the underlying mechanisms remain unclear. Given that AKG is the primary substrate of oxoglutarate dehydrogenase (OGDH), this study aimed to investigate how OGDH mediates the protective role of AKG against oxidative stress and in supporting follicular development.

resultAKG treatment advanced puberty onset and increased the number of corpora lutea in mice. It alleviated oxidative stress and apoptosis in granulosa cells by upregulating CAT and downregulating P53. Crucially, OGDH physically interacted with CAT and SOD2 and boosted their enzymatic activities, thereby reinforcing AKG’s antioxidative effects. Knockdown of OGDH markedly impaired the ability of AKG to promote follicular development.

conclusionsThese findings identify OGDH as a key mediator of AKG’s protective role in follicular development through modulation of oxidative stress and apoptosis. This work provides mechanistic insight into AKG function and supports its potential as a therapeutic strategy for follicular disorders.

Indexed as

AntioxidantsCatalaseGranulosa CellsKetoglutarate Dehydrogenase ComplexKetoglutaric AcidsOvarian FollicleOxidative StressSuperoxide DismutaseAnimalsApoptosisFemaleMiceSuperoxide Dismutase 2AntioxidantsCatalaseKetoglutarate Dehydrogenase ComplexKetoglutaric AcidsSuperoxide DismutaseSuperoxide Dismutase 2Alpha-Ketoglutaric acidFollicular disorderGranulosa cellsOGDH

Identifiers

PMID41964037
PMCPMC13200353

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.