Evidence map›Paper›PMID 41964009›Full record

ArticleJournal of nanobiotechnology2026

Palladium nanozyme loaded metal-organic framework eyedrops alleviate oxidative stress for dry eye treatment.

Yajia Wang, Jiang Chen, Renjie Zhang, Chunyi Weng, Di Hu, Wenpei Jiang, Yingying Zhou, Quankui Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yajia WangNational Engineering Research Center of Ophthalmology and Optometry, School of Biomedical Engineering, School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Jiang ChenNational Engineering Research Center of Ophthalmology and Optometry, School of Biomedical Engineering, School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Renjie ZhangNational Engineering Research Center of Ophthalmology and Optometry, School of Biomedical Engineering, School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Chunyi WengNational Engineering Research Center of Ophthalmology and Optometry, School of Biomedical Engineering, School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Di HuNational Engineering Research Center of Ophthalmology and Optometry, School of Biomedical Engineering, School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Wenpei JiangNational Engineering Research Center of Ophthalmology and Optometry, School of Biomedical Engineering, School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Yingying ZhouNational Engineering Research Center of Ophthalmology and Optometry, School of Biomedical Engineering, School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Quankui LinNational Engineering Research Center of Ophthalmology and Optometry, School of Biomedical Engineering, School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China. linqk@wmu.edu.cn.

Funding

Zhejiang Provincial Natural Science Foundation LR23H180001
6 · The paper itself

Abstract

Dry eye is a multifactorial ocular disorder caused by reduced tear secretion, poor tear quality, or excessive tear evaporation, which is a major public health issue worldwide. Oxidative stress on the ocular surface leading to excessive reactive oxygen species (ROS) production is considered a primary factor in the pathogenesis of dry eye. Herein, we designed a palladium (Pd) -loaded metal-organic framework (MOF) nanoparticle (PdM) as nanozyme eyedrops for dry eye treatment via efficient removal of various ROS. Experimental results confirmed that PdM nanozyme has multiple antioxidant enzyme activities and could scavenge a variety of free radicals. Furthermore, in vitro studies demonstrated its capacity to alleviate excess intracellular ROS, protect cytoskeletal structures and intercellular tight junctions. Treatment outcomes in animal models of dry eye confirmed its therapeutic efficacy in reducing corneal epithelial cell damage and inflammation, offering a novel approach for dry eye treatment.

Indexed as

Dry Eye SyndromesMetal-Organic FrameworksNanoparticlesOphthalmic SolutionsOxidative StressPalladiumAnimalsAntioxidantsHumansRabbitsReactive Oxygen SpeciesAntioxidantsMetal-Organic FrameworksOphthalmic SolutionsPalladiumReactive Oxygen SpeciesCell protectionDry eyeNanozymePd-loaded MOF nanoparticleROS

Identifiers

PMID41964009
PMCPMC13200507

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.