Evidence map›Paper›PMID 41963704›Full record

ArticleIn vitro cellular & developmental biology. Animal2026

RYK silencing-modified bone marrow-derived mesenchymal stem cells suppress gastric cancer progression.

Yongan Fu, Zongda Cai, Yangqiang Wang, Mingjin Huang, Jinghua Huang

Abstract read
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In one paragraph

Article in In vitro cellular & developmental biology. Animal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yongan FuDepartment of Gastrointestinal Surgery, Quanzhou First Affiliated Hospital to Fujian Medical University, 250 East Street, Quanzhou, Fujian, 362000, P.R. China.
Zongda CaiDepartment of Gastrointestinal Surgery, Quanzhou First Affiliated Hospital to Fujian Medical University, 250 East Street, Quanzhou, Fujian, 362000, P.R. China.
Yangqiang WangDepartment of Gastrointestinal Surgery, Quanzhou First Affiliated Hospital to Fujian Medical University, 250 East Street, Quanzhou, Fujian, 362000, P.R. China.
Mingjin HuangDepartment of Gastrointestinal Surgery, Quanzhou First Affiliated Hospital to Fujian Medical University, 250 East Street, Quanzhou, Fujian, 362000, P.R. China.
Jinghua HuangDepartment of Gastrointestinal Surgery, Quanzhou First Affiliated Hospital to Fujian Medical University, 250 East Street, Quanzhou, Fujian, 362000, P.R. China. hjhqzsy@163.com.ORCID http://orcid.org/0009-0003-7903-6574

Funding

Natural Science Foundation of Fujian Province 2021J011405Natural Science Foundation of Fujian Province 2024J011522
6 · The paper itself

Abstract

Gastric cancer (GC) is a prevalent malignant tumor threatening human health. This study aimed to explore the potential mechanism of receptor-like tyrosine kinase (RYK) silencing-modified bone marrow-derived mesenchymal stem cells (BMSCs) in the progression of GC. BMSCs were transfected with the RYK siRNA and negative controls. Cell co-culture experiments were used to explore the interaction between different BMSCs and human gastric carcinoma cell line NCI-N87. Cancer cell proliferation, cell cycle, apoptosis, colony formative ability, and invasive ability were assessed. Western blot analysis was performed to determine the protein levels of cyclinA, Bcl-xL, Bcl-2, cleaved caspase 3, cleaved caspase 7, cleaved caspase 9, and cleaved PARP1 in NCI-N87 cells. Compared with NCI-N87 cells, co-culture of si-NC-modified BMSCs with NCI-N87 cells promoted the proliferation, colony formative ability, and invasion of NCI-N87 cells, inhibited the apoptosis of NCI-N87 cells, and reduced the proportion of NCI-N87 cells present in G2/M phase cells. In addition, compared with the si-NC-BMSCs + N87 group, the si-RYK-BMSCs + N87 group inhibited the proliferation, colony formative ability, and invasion of NCI-N87 cells, promoted the apoptosis of NCI-N87 cells, and increased the proportion of G2/M phase cells. Thus, RYK silencing-modified BMSCs can inhibit the proliferation, colony formative ability, and invasion of NCI-N87 cells, while inducing apoptosis and G2/M phase arrest.

Indexed as

Bone Marrow CellsDisease ProgressionGene SilencingMesenchymal Stem CellsStomach NeoplasmsAnimalsApoptosisCell CycleCell Line, TumorCell ProliferationCoculture TechniquesHumansNeoplasm InvasivenessRNA, Small InterferingRNA, Small InterferingBone marrow-derived mesenchymal stem cellsGastric cancerProgressionRYK

Identifiers

PMID41963704

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.