ArticleActa pharmacologica Sinica2026
Astrocytic apelin mediates cortical neuronal function and prevents anxiety-like behaviors in mice.
Article in Acta pharmacologica Sinica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As a key adipokine that regulates vascular functions, apelin has recently been appreciated for its role in modulating brain functions, including its potential use in treating mental diseases. However, the precise mechanism has not been fully illustrated. Here, we demonstrate that the deprivation of astrocytic apelin in the medial prefrontal cortex led to anxiety-like behaviors in mice, accompanied by defects in neuronal dendritic morphology and neural activity. Conversely, the central replenishment of apelin reversed the behavioral deficits in these conditional knockdown models. Intervention using central apelin also effectively attenuated neuronal structural deficits and anxiety-like behaviors in mice under chronic restraint stress. These results broaden our understanding of the role of apelin in modulating mental functions and provide more possibilities for targeted interventions in mental diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.