Evidence map›Paper›PMID 41963618›Full record

ArticleOncogene2026

The impact of K-Ras Gly12 mutants on homeostasis and tumorigenesis in the colonic epithelium.

Moon Hee Yang, Shikha Sheth, Bing Shui, Isabella N Grabski, Samuel Seongmin Park, Ana Cobo, Rafael Irizarri, John V Heymach, Lukas E Dow, Kevin M Haigis

Abstract read
In one paragraph

Article in Oncogene, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Moon Hee Yang *Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Shikha Sheth *Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Bing ShuiDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Isabella N GrabskiDepartment of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.
Samuel Seongmin ParkDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Ana CoboDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0002-0988-1823
Rafael IrizarriDepartment of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.
John V HeymachDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0001-9068-8942
Lukas E DowSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-7048-1418
Kevin M HaigisDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. Kevin_Haigis@dfci.harvard.edu.ORCID http://orcid.org/0000-0003-1922-4509

Funding

Basic and Translational studies of Ras-mutant colorectal cancerR01CA178017 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI HAIGIS, KEVIN · 2014 to 2018
$1.8M
CCR NIH HHS HHSN261200800001CNCI NIH HHS R01 CA178017NIH HHS HHSN261200800001EU.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01-CA178017
6 · The paper itself

Abstract

K-Ras represents one of the most frequently mutated and therapeutically relevant oncogenic drivers. Clinical and epidemiological data suggest association between specific KRAS alleles, therapeutic responses, and patient outcomes, however, direct experimental validation of these relationships has been limited. In this study, we investigate the differential impacts of three most common K-Ras G12 mutants (K-Ras

Indexed as

CarcinogenesisColonColonic NeoplasmsHomeostasisIntestinal MucosaMutationProto-Oncogene Proteins p21(ras)AllelesAnimalsCell Transformation, NeoplasticHumansMiceProto-Oncogene Proteins p21(ras)

Identifiers

PMID41963618
PMCPMC13139037

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.