Evidence map›Paper›PMID 41963607›Full record

ArticleNature metabolism2026

iNOS modulates inflammatory responses in an NO-independent manner through direct interaction with IRG1 in mitochondria.

Marina Diotallevi, Carlos Outeiral, Priyanka Patel, Gareth S D Purvis, Surawee Chuaiphichai, Thomas Nicol, Faseeha Ayaz, Daniel A Nissley, Ganna O Krasnoselska, Svenja Hester and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Itaconate metabolism in regulated cell death.Molecular and cellular biochemistry · 2026
    Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Marina DiotalleviBHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK. marina.diotallevi@cardiov.ox.ac.uk.ORCID http://orcid.org/0000-0001-7982-5678
Carlos OuteiralOxford Protein Informatics Group, University of Oxford, Oxford, UK.
Priyanka PatelDepartment of Biochemical Sciences, School of Biosciences and Medicine, University of Surrey, Guildford, UK.ORCID http://orcid.org/0009-0007-6425-1182
Gareth S D PurvisBHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Surawee ChuaiphichaiBHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-7512-6252
Thomas NicolBHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Faseeha AyazBHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Daniel A NissleyOxford Protein Informatics Group, University of Oxford, Oxford, UK.
Ganna O KrasnoselskaStructural Biology, Rosalind Franklin Institute, Harwell Science Campus, Didcot, UK.
Svenja HesterTarget Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
John H McVeyDepartment of Biochemical Sciences, School of Biosciences and Medicine, University of Surrey, Guildford, UK.
Roman FischerTarget Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-9715-5951
Benedikt KesslerTarget Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Charlotte M DeaneOxford Protein Informatics Group, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-1388-2252
Raymond J OwensStructural Biology, Rosalind Franklin Institute, Harwell Science Campus, Didcot, UK.
Keith M Channon *BHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK. keith.channon@cardiov.ox.ac.uk.ORCID http://orcid.org/0000-0002-1043-4342
Mark J Crabtree *BHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK. mark.crabtree@surrey.ac.uk.ORCID http://orcid.org/0000-0003-3298-2697

Funding

BHF Centre of Research Excellence, Oxford (BHF Centre of Research Excellence in Oxford) RE/13/1/30181BHF Centre of Research Excellence, Oxford (BHF Centre of Research Excellence in Oxford) RG/F/22/110085British Heart Foundation (BHF) FS/14/56/31049British Heart Foundation (BHF) RE/18/3/34214British Heart Foundation (BHF) RG/17/10/32859RCUK | Engineering and Physical Sciences Research Council (EPSRC) EP/ S025243/1RCUK | Engineering and Physical Sciences Research Council (EPSRC) EP/W522582/1
6 · The paper itself

Abstract

Nitric oxide (NO) has fundamental roles in numerous physiological and pathophysiological processes. In macrophages, NO produced by inducible nitric oxide synthase (iNOS) modulates metabolic changes that are essential to macrophage activation and plasticity, driving the characteristic metabolic switch from oxidative phosphorylation to glycolysis

Indexed as

Carboxy-LyasesInflammationMitochondriaNitric OxideNitric Oxide Synthase Type IIAnimalsHumansHydro-LyasesMacrophagesMiceSuccinatesAcod1 protein, mouseCarboxy-LyasesHydro-Lyasesitaconic acidNitric OxideNitric Oxide Synthase Type IINos2 protein, mouseSuccinates

Identifiers

PMID41963607
PMCPMC13121041

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.