Evidence map›Paper›PMID 41963593›Full record

ArticleLeukemia2026

mRNA vaccination targeting AML1::ETO fusion gene eliminates leukemia cells via activating T cells.

Changli Zhou, Sicheng Bian, Jiuxia Pang, Huiqin Bian, Tao Cheng, Hiroaki Koyama, Bin Liu, Bing Li, William Tse, Shujun Liu

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Changli Zhou *Department of Medicine, The MetroHealth System, Case Western Reserve University, 2500 Metro Health Drive, Cleveland, OH, 44109, USA.ORCID http://orcid.org/0000-0002-5984-4289
Sicheng Bian *Department of Medicine, The MetroHealth System, Case Western Reserve University, 2500 Metro Health Drive, Cleveland, OH, 44109, USA.ORCID http://orcid.org/0000-0001-9527-2102
Jiuxia Pang *Department of Medicine, The MetroHealth System, Case Western Reserve University, 2500 Metro Health Drive, Cleveland, OH, 44109, USA.
Huiqin BianDepartment of Medicine, The MetroHealth System, Case Western Reserve University, 2500 Metro Health Drive, Cleveland, OH, 44109, USA.
Tao ChengDepartment of Medicine, The MetroHealth System, Case Western Reserve University, 2500 Metro Health Drive, Cleveland, OH, 44109, USA.
Hiroaki KoyamaDepartment of Medicine, The MetroHealth System, Case Western Reserve University, 2500 Metro Health Drive, Cleveland, OH, 44109, USA.
Bin LiuHormel Institute, University of Minnesota, 801 16th Ave NE, Austin, MN, 55912, USA.ORCID http://orcid.org/0000-0002-6581-780X
Bing LiDepartment of Pathology, The University of Iowa, 431 Newton Road, Iowa City, IA, 52242, USA.
William TseDepartment of Medicine, The MetroHealth System, Case Western Reserve University, 2500 Metro Health Drive, Cleveland, OH, 44109, USA.
Shujun LiuDepartment of Medicine, The MetroHealth System, Case Western Reserve University, 2500 Metro Health Drive, Cleveland, OH, 44109, USA. shujun.liu2@case.edu.ORCID http://orcid.org/0000-0002-5347-8345

Funding

The Role of HIF1A-DNMT3A axis in AML1/ETO-Driven Acute MyelogenousLeukemiaR01CA248019 · NCI · UNIVERSITY OF MINNESOTA · PI LIU, SHUJUN · 2021 to 2025
$3.2M
Role of an Aberrant N6-Methyladenosine-LncRNA Axis in the Development and Maintenance of Drug Resistance through Regulating the Leukemia Stem CellR01CA266256 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, GANG, LIU, SHUJUN · 2022 to 2025
$3.0M
Targeting aberrant epigenetics by nanomedicineR01CA149623 · NCI · UNIVERSITY OF MINNESOTA · PI LIU, SHUJUN · 2010 to 2014
$1.8M
NCI NIH HHS R01 CA149623NCI NIH HHS R01 CA248019NCI NIH HHS R01 CA266256U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01CA248019U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01CA266256
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID41963593
PMCPMC13233333

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.