Evidence map›Paper›PMID 41963558›Full record

SynthesisJournal of neurology2026

Effect of exercise training on clinical and physiological variables in adults with myotonic dystrophy type 1: a systematic review and meta-analysis.

Saidan Shetty, Yuting Luo, Aruna Thomas, Khalid Gamil, Ishita Saxena, Subharup Guha, Ravneet Vohra, Donovan J Lott

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Saidan ShettyDepartment of Anatomy, Melaka Manipal Medical College-Manipal Campus, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, 576104, India.ORCID http://orcid.org/0000-0001-6852-5178
Yuting LuoRehabilitation Science PhD Program, University of Florida, Gainesville, FL, USA.
Aruna ThomasDepartment of Physical Therapy, University of Florida, Gainesville, FL, USA.
Khalid GamilRehabilitation Science PhD Program, University of Florida, Gainesville, FL, USA.
Ishita SaxenaDepartment of Computing and Data Sciences, Boston University, Boston, MA, USA.
Subharup GuhaDepartment of Biomedical Data Science, Dartmouth College, Lebanon, NH, USA.ORCID http://orcid.org/0000-0002-5524-1827
Ravneet VohraDoctor of Physical Therapy Program, University of Louisiana, Monroe, LA, USA.
Donovan J LottDepartment of Physical Therapy, University of Florida, Gainesville, FL, USA. djlottpt@phhp.ufl.edu.ORCID http://orcid.org/0000-0002-9072-8630

Funding

The Boston Lung Cancer Survival CohortU01CA209414 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI David C Christiani · 2017 to 2026
$12.2M
Detecting racial disparities in cancer survival by integrating multiple high-dimensional observational studiesR01CA269398 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GUHA, SUBHARUP, LI, YI · 2022 to 2025
$1.3M
NCI NIH HHS R01 CA269398NCI NIH HHS U01 CA209414NIAMS NIH HHS R01 AR076060-01A1NIH HHS CA209414NIH HHS CA269398
6 · The paper itself

Abstract

Myotonic dystrophy type 1 (DM1) is a progressive neuromuscular disorder characterized by muscle weakness, fatigue, reduced endurance, and impaired quality of life. This systematic review and meta-analysis aimed to evaluate the effects of exercise training on clinical and physiological outcomes in adults with DM1. Six databases were searched for studies published between 2003 and 2023. Randomized controlled trials, quasi-experimental studies, and longitudinal cohort studies involving adults with DM1 undergoing aerobic or resistance training were included, and risk of bias was assessed. Meta-analyses used standardized mean differences with fixed- or random-effects models based on heterogeneity. Fourteen studies were included. Most studies demonstrated low risk of bias. Only one study reported any adverse events, and the incidence of these events was similar in occurrence between the intervention and standard care only groups. Meta-analysis demonstrated a moderate improvement in strength (p = 0.022). Endurance showed a large but non-significant pooled effect (p = 0.14). Meta-analyses for fatigue (p = 0.49) and sleep (p > 0.05) were inconclusive. Narrative synthesis indicated improvements in most clinical and physiological outcomes, while sleep outcomes showed minimal or inconsistent changes across studies. Exercise training appears safe and provides moderate benefits for strength and selected clinical and physiological outcomes in adults with DM1. Future well-powered trials with standardized protocols are needed to optimize exercise prescription.

Indexed as

Exercise TherapyMyotonic DystrophyAdultHumansMuscle StrengthAerobic trainingExercise trainingMyotonic dystrophy type 1Resistance training; muscle strengthSystematic review and meta-analysis

Identifiers

PMID41963558
PMCPMC13101884

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.