ArticleThe EMBO journal2026
Convergent evolution of aerobic fermentation through divergent mechanisms acting on key shared glycolytic genes.
Article in The EMBO journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- mSphere of Influence: Embracing biological complexity.mSphere · 2026Article
- Article
- The macroevolution of filamentation morphology across the Saccharomycotina yeast subphylum.FEMS yeast research · 2026Article
- The Macroevolution of Filamentation Morphology Across thebioRxiv : the preprint server for biology · 2025Article
- A trait syndrome ties cell morphology to glycolysis across the yeast subphylum.bioRxiv : the preprint server for biology · 2025Article
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Abstract
As the tree of life becomes increasingly accessible to molecular investigations, describing mechanisms underlying evolutionary convergence and constraint will be crucial to understanding diversification. The lineage including the model yeast Saccharomyces cerevisiae evolved aerobic fermentation in part through an ancient whole genome duplication and retention of glycolytic genes. To evaluate glycolytic rates across diverse yeasts, we developed and deployed an extracellular acidification rates (ECAR) assay on 299 species that span more than 400 million years of evolution and identified a clade in the genus Saturnispora that convergently evolved aerobic fermentation. Through comparative genomics and transcriptomics, we found that several glycolytic genes had higher expression and novel cis-regulatory elements in aerobically fermenting Saturnispora species. When the transcription factor required for their activation was deleted in Saturnispora dispora, the mutants had reduced glycolytic rates and increased respiration. Intriguingly, many of the upregulated genes are orthologous to duplicated glycolytic genes in S. cerevisiae. These divergent genetic mechanisms affecting the same set of genes suggest that there are strong evolutionary constraints on how aerobic fermentation can arise.
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