ArticleJournal of bone and mineral metabolism2026
Incident subclinical vertebral fractures and health-related quality of life: JPOS cohort study.
Article in Journal of bone and mineral metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Response to the Letter to the Editor, Commentary on "Incident subclinical vertebral fractures and health-related quality of life: JPOS cohort study".Journal of bone and mineral metabolism · 2026Article
- Commentary on "Incident subclinical vertebral fractures and health-related quality of life: JPOS cohort study".Journal of bone and mineral metabolism · 2026Article
- Reply to: Comment on "Bone fragility and atypical femoral fractures in SLE-role of disease activity, infection, and treatment".Journal of bone and mineral metabolism · 2026Article
- Comment on "Bone fragility and atypical femoral fractures in SLE: role of disease activity, infection, and treatment".Journal of bone and mineral metabolism · 2026Article
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21 authors.
Funding
Abstract
introductionVertebral fractures are the most common osteoporotic fractures, yet approximately two-thirds of radiographically detectable fractures remain clinically unrecognized. The longitudinal impact of such subclinical vertebral fractures on health-related quality of life (HRQOL) is not fully clarified. This study examined whether incident subclinical vertebral fractures were associated with subsequent changes in HRQOL. MATERIALS AND
methodsThis study was nested within the Japanese Population-based Osteoporosis (JPOS) Cohort. Community-dwelling women aged ≥ 50 years without clinical fractures were included. Incident subclinical vertebral fractures, assessed by single-energy X-ray absorptiometry-based vertebral fracture assessment with morphometry, were the primary exposure. HRQOL was evaluated using Japanese SF-36® v2. General linear models estimated associations between incident fractures and follow-up SF-36® subscale scores, adjusting for baseline HRQOL and prespecified covariates. Sensitivity analyses excluding participants with pre-baseline subclinical vertebral fractures or with anti-osteoporosis medication were performed.
resultsOf 344 participants, 53 (15.4%) developed incident subclinical vertebral fractures. Baseline SF-36® standardized subscale scores did not differ between groups. At follow-up, women with incident fractures had significantly lower physical functioning and social functioning scores. After multivariable adjustment, social functioning remained significantly lower in the fracture group (false discovery rate-adjusted p = 0.028). Social functioning declined progressively with increasing fracture number and was significantly lower in lumbar fractures. Sensitivity analyses yielded consistent results with primary analyses.
conclusionsIncident subclinical vertebral fractures among community-dwelling Japanese women were independently associated with clinically meaningful declines in social functioning, suggesting the importance of early identification to prevent deterioration in HRQOL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.