Evidence map›Paper›PMID 41963394›Full record

ArticleScientific reports2026

Green synthesis, characterization, evaluation of anticancer and antioxidant potentials of gold and copper oxide nanoparticles using jujube fruit extract.

Hatice Demir Becerekli, Filiz Akbaş

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hatice Demir BecerekliTechnical Sciences Vocational School, Batman University, Batman, 72100, Turkey. hatice.becerekli@batman.edu.tr.
Filiz AkbaşDepartments of Biology, Faculty of Science and Literature, Batman University, Batman, 72100, Turkey.

Funding

The Batman University Scientific Research Projects Coordination BTÜBAP-2024-Doktora-01
6 · The paper itself

Abstract

Metallic nanoparticles synthesized via plant extracts under green chemistry principles exhibit unique physicochemical and biological properties. In this study, for the first time, gold nanoparticles (AuNPs) and copper oxide nanoparticles (CuO NPs) were synthesized using Ziziphus jujuba Mill. fruit extract as a natural reducing and stabilizing agent. The biosynthesized nanoparticles were comprehensively characterized by UV-Vis, SEM-EDX, TEM, FTIR, XRD, and DLS analyses, confirming their nanoscale size, crystalline structure, and surface functionalization by plant-derived biomolecules. The antioxidant potential of the nanoparticles was evaluated using DPPH and ABTS radical scavenging assays, revealing effective free radical scavenging activity, with AuNPs exhibiting comparatively higher antioxidant performance. Cytotoxicity studies performed on A549, MDA-MB-231, and SH-SY5Y cancer cell lines demonstrated a significant, concentration-dependent reduction in cell viability, while relatively lower toxicity was observed in healthy L929 fibroblast cells. Notably, CuO NPs showed stronger cytotoxic effects compared to AuNPs, highlighting differences in their biological behavior. This study emphasizes the novelty of jujube fruit extract-mediated synthesis of both AuNPs and CuO NPs and demonstrates their promising antioxidant and anticancer potential, underscoring the role of plant-derived phytochemicals in the development of sustainable nanomaterials for biomedical applications.

Indexed as

Antineoplastic AgentsAntioxidantsCopperFruitGoldMetal NanoparticlesPlant ExtractsZiziphusAnimalsCell Line, TumorCell SurvivalGreen Chemistry TechnologyHumansAntineoplastic AgentsAntioxidantsCoppercuprous oxideGoldjujube extractPlant ExtractsAnticancerAntioxidantAuNPCharacterizationCuO NPsGreen synthesisJujube

Identifiers

PMID41963394
PMCPMC13201602

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.