Evidence map›Paper›PMID 41963373›Full record

ArticleNPJ vaccines2026

An ESAT-6-convergent prime-boost vaccination combining recombinant BCG expressing Mycobacterium marinum ESX-1 and ESAT-6/GLA-SE improves TB protection.

Kee Woong Kwon, Hongmin Kim, Hagyu Kim, Roland Brosch, Sung Jae Shin

Abstract read
In one paragraph

Article in NPJ vaccines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kee Woong Kwon *Department of Microbiology, College of Medicine, Gyeongsang National University, Jinju, South Korea.
Hongmin Kim *Department of Microbiology, Yonsei University College of Medicine, Seoul, South Korea.
Hagyu KimDepartment of Microbiology, Yonsei University College of Medicine, Seoul, South Korea.
Roland BroschInstitut Pasteur, Université Paris Cité, CNRS UMR 6047, Unit for Integrated Mycobacterial Pathogenomics, Paris, France. roland.brosch@pasteur.fr.
Sung Jae ShinDepartment of Microbiology, Yonsei University College of Medicine, Seoul, South Korea. sjshin@yuhs.ac.

Funding

Korea Health Industry Development Institute RS-2025-02173063Ministry of Food and Drug Safety 26202MFDS013National Research Foundation of Korea RS-2023-00208115
6 · The paper itself

Abstract

Although Bacille Calmette-Guérin (BCG) protects children against disseminated tuberculosis (TB), its limited efficacy against adult pulmonary TB underscores the need for improved vaccination strategies. We previously developed a recombinant BCG strain expressing the ESX-1 type VII secretion system of Mycobacterium marinum (BCG::ESX-1

Identifiers

PMID41963373
PMCPMC13253831

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.