Evidence map›Paper›PMID 41963315›Full record

ArticleNature communications2026

Spin-driven enantioselective regulation of cyclooxygenase-2 activity for rheumatoid arthritis therapy via chiral gold nanohelices.

Jiao Yan, Lai Liu, Zhihao Chen, Qian Zhao, Xiaoqing Han, Yanjing Wang, Zhengzhi Mu, Xingbo Wang, Panpan Song, Yaqing Kang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Stimuli-Responsive Nanoplatforms for Precision Intervention in Rheumatoid Arthritis.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jiao Yan *The Key Laboratory of Advanced Interdisciplinary Studies, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.ORCID http://orcid.org/0000-0001-7303-316X
Lai Liu *Hunan Key Laboratory for Super-Microstructure and Ultrafast Process, School of Physics, Central South University, Changsha, China.ORCID http://orcid.org/0009-0007-4353-7501
Zhihao ChenThe Key Laboratory of Advanced Interdisciplinary Studies, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Qian ZhaoHunan Key Laboratory for Super-Microstructure and Ultrafast Process, School of Physics, Central South University, Changsha, China.ORCID http://orcid.org/0009-0009-2608-1850
Xiaoqing HanLaboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.ORCID http://orcid.org/0000-0003-4722-9083
Yanjing WangThe Key Laboratory of Advanced Interdisciplinary Studies, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Zhengzhi MuKey Laboratory of Bionic Engineering, Ministry of Education, Jilin University, Changchun, China.
Xingbo WangSchool of Biomedical Engineering, Guangzhou Medical University, Guangzhou, China.
Panpan SongThe Key Laboratory of Advanced Interdisciplinary Studies, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.ORCID http://orcid.org/0000-0002-8474-4191
Yaqing KangThe Key Laboratory of Advanced Interdisciplinary Studies, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Weijie LuDepartment of Orthopedics, Yanjiang Hospital, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Ai-Min GuoHunan Key Laboratory for Super-Microstructure and Ultrafast Process, School of Physics, Central South University, Changsha, China. aimin.guo@csu.edu.cn.ORCID http://orcid.org/0000-0003-2662-8990
Qing-Feng SunInternational Center for Quantum Materials, School of Physics, Peking University, Beijing, China.ORCID http://orcid.org/0000-0002-5512-9608
Haiyuan ZhangThe Key Laboratory of Advanced Interdisciplinary Studies, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. hzhang@gzhmu.edu.cn.ORCID http://orcid.org/0000-0003-4076-1771

Funding

Department of Science and Technology of Jilin Province (Jilin Province Science and Technology Department) 20240101188JCHunan Provincial Science and Technology Department (Department of Science and Technology of Hunan Province) 2023JJ10058National Natural Science Foundation of China (National Science Foundation of China) 32301181, 22077119, 12274466, 11874428, 11921005, 12374034
6 · The paper itself

Abstract

Electron-spin dynamics represent an additional dimension in enzymatic catalysis, where most regulatory strategies focus on modulating active-site chemistry. Here, we present a spintronic approach that employs chiral gold nanohelices (

Indexed as

Arthritis, ExperimentalArthritis, RheumatoidCyclooxygenase 2Cyclooxygenase 2 InhibitorsGoldMetal NanoparticlesAnimalsDinoprostoneHumansMaleMiceMice, Inbred DBAStereoisomerismCyclooxygenase 2Cyclooxygenase 2 InhibitorsDinoprostoneGold

Identifiers

PMID41963315
PMCPMC13376605

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.