Evidence map›Paper›PMID 41963084›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2026

Activation by Alcohol of Prefrontal Layer 5 Pyramidal Neurons Depends on Ascending Dopaminergic Input.

Miao Li, David Cabrera-Garcia, Neil L Harrison, Guang Yang

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Miao LiDepartment of Anesthesiology, Columbia University, New York, New York 10032.ORCID https://orcid.org/0009-0005-5419-8432
David Cabrera-GarciaDepartment of Anesthesiology, Columbia University, New York, New York 10032.ORCID https://orcid.org/0000-0001-9609-9102
Neil L HarrisonDepartment of Anesthesiology, Columbia University, New York, New York 10032 nh2298@columbia.edu gy2268@cumc.columbia.edu.ORCID https://orcid.org/0000-0002-8013-7765
Guang YangDepartment of Anesthesiology, Columbia University, New York, New York 10032 nh2298@columbia.edu gy2268@cumc.columbia.edu.ORCID https://orcid.org/0000-0002-5739-9126

Funding

The roles of anesthetics and neuroimmune interactions in postoperative cognitive dysfunctionR35GM131765 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Guang Yang · 2019 to 2026
$3.4M
Alcohol and Interneurons in the Prefrontal CortexR01AA030604 · NIAAA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI NEIL L. HARRISON · 2023 to 2026
$1.9M
NIAAA NIH HHS R01 AA030604NIGMS NIH HHS R35 GM131765
6 · The paper itself

Abstract

Short-term alcohol exposure modulates activity in reward-related regions such as the ventral tegmental area (VTA) and executive cortical regions such as the prefrontal cortex (PFC), potentially contributing to alcohol use disorders. Although alcohol induces dopamine release from VTA projection neurons, how dopamine signaling contributes to the acute effects of alcohol in the PFC at the cellular level remains unclear. Using in vivo Ca

Indexed as

Central Nervous System DepressantsDopamineDopaminergic NeuronsEthanolPrefrontal CortexPyramidal CellsAnimalsFemaleMaleMiceMice, Inbred C57BLReceptors, Dopamine D1Ventral Tegmental AreaCentral Nervous System DepressantsDopamineEthanolReceptors, Dopamine D1alcoholdopamineprefrontal cortexVTA

Identifiers

PMID41963084
PMCPMC13166099

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.