ArticleJournal for immunotherapy of cancer2026
CD55-expressing myeloid-derived suppressor cells (MDSCs) drive cancer immunoevasion.
Article in Journal for immunotherapy of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMyeloid-derived suppressor cells (MDSCs) play a pivotal role in shaping the immunosuppressive tumor microenvironment, thereby driving tumor progression and contributing to resistance to therapy. The surface molecules expressed on MDSCs serve not only as identification markers but also as critical regulators of their immunosuppressive functions. Identifying surface markers that are both widely expressed and functionally significant on MDSCs is essential for the development of effective immunomodulatory therapies.
methodsA comprehensive analysis of publicly available single-cell RNA-seq datasets across eight cancer types was conducted to identify conserved surface markers on MDSCs. CD55 was identified as a promising candidate and subsequently validated in both human patient samples and murine tumor models. Mechanistic investigations employed CD55 knockout and myeloid-specific knockout mice, bone marrow transplantation, DNA pulldown assays, chromatin immunoprecipitation, luciferase reporter assays, co-immunoprecipitation, immunoblotting, immunoprecipitation-mass spectrometry, and RNA sequencing. To evaluate the therapeutic potential of targeting CD55, molecular docking analyses, small-molecule inhibitor screening, and surface plasmon resonance imaging-based competitive binding assays were conducted.
resultsCD55 was consistently overexpressed on MDSCs across multiple cancer types, with its expression correlating with poor patient prognosis. Genetic depletion of CD55 significantly inhibited tumor growth and enhanced antitumor immunity by reducing MDSCs infiltration and boosting CD8
conclusionThis study identified CD55 as a key regulator of MDSCs-mediated tumor immunosuppression via metabolic reprogramming. Targeting CD55 on MDSCs offers a promising therapeutic approach to overcoming immunosuppression and enhancing the efficacy of cancer immunotherapy.
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