Evidence map›Paper›PMID 41962901›Full record

ArticleMucosal immunology2026

The Nox2 NADPH oxidase regulates neutrophilic inflammation in the oral cavity.

Shunying Jin, Richa Singhal, Jianzhu Luo, Yasmine H Higgins, Kelley N Cooper, Marina Terekhova, Katherine A Carey, Audrey F Duff, Maxim N Artyomov, Venkatakrishna R Jala and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mucosal immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Shunying JinDepartment of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, KY, United States.
Richa SinghalDepartment of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, KY, United States.
Jianzhu LuoDepartment of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, KY, United States.
Yasmine H HigginsCenter for Microbe and Immunity Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, United States.
Kelley N CooperCenter for Microbe and Immunity Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, United States.
Marina TerekhovaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, United States.
Katherine A CareyCenter for Microbe and Immunity Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, United States.
Audrey F DuffCenter for Microbe and Immunity Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, United States.
Maxim N ArtyomovDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, United States.
Venkatakrishna R JalaDepartment of Microbiology and Immunology, Brown Cancer Center, School of Medicine, University of Louisville, Louisville, KY, United States.
Rachel A IdolDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO, United States.
Michael T BaileyCenter for Microbe and Immunity Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, United States.
Mary C DinauerDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO, United States.
Richard J LamontDepartment of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, KY, United States.
Juhi BagaitkarCenter for Microbe and Immunity Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, United States; Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH, United States. Electronic address: Juhi.bagaitkar@nationwidechildrens.org.

Funding

Redox Regulation of Gingival InflammationR01DE028296 · NIDCR · UNIVERSITY OF LOUISVILLE · PI BAGAITKAR, JUHI · 2020 to 2024
$2.3M
A novel role for NADPH oxidase in modulating neutrophil functions in periodontal diseaseR03DE028031 · NIDCR · UNIVERSITY OF LOUISVILLE · PI BAGAITKAR, JUHI · 2018 to 2019
$308k
NIDCR NIH HHS R01 DE028296NIDCR NIH HHS R03 DE028031
6 · The paper itself

Abstract

The leukocyte NADPH oxidase 2 (Nox2) is an important regulator of inflammatory responses, independent of its antimicrobial activity. Inactivating mutations in NOX2 cause chronic granulomatous disease (CGD), a severe immunodeficiency associated with recurrent infections and dysregulated neutrophilic inflammation. Recurrent oral ulcers, stomatitis, gingivitis, and other inflammatory issues affecting the oral mucosa have been observed in patients with CGD; however, the underlying mechanisms are not known. Here, we present evidence that the extensive inflammatory destruction of oral mucosal tissues observed in Nox2-deficient or Cybb

Indexed as

Granulomatous Disease, ChronicInflammationMouthMouth MucosaNADPH Oxidase 2NeutrophilsAnimalsCytokinesDisease Models, AnimalHumansMiceMice, KnockoutNeutrophil InfiltrationNF-E2-Related Factor 2Reactive Oxygen SpeciesCybb protein, mouseCytokinesNADPH Oxidase 2NF-E2-Related Factor 2Reactive Oxygen Species

Identifiers

PMID41962901
PMCPMC13282637

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.