Evidence map›Paper›PMID 41962536›Full record

ArticleCurrent biology : CB2026

Acute requirement for the hippocampus in putatively conscious vision revealed by a mouse model of blindsight.

Nikhil Bhatla, Kathryn Cheong, Sho Takahashi, Corliss Lay, Matthew Fiedeldey, Kathleen Liang, Mo Mao, Yun-Fan Wu, Sandy Lu, Karis Yun and 20 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

30 authors.

Nikhil BhatlaInstitute for All Minds, Berkeley, CA 94704, USA; Department of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Miller Institute for Basic Research, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: nikhil@iam.science.
Kathryn CheongDepartment of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Sho TakahashiDepartment of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Corliss LayDepartment of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Matthew FiedeldeyDepartment of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Kathleen LiangDepartment of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Mo MaoDepartment of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Yun-Fan WuDepartment of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Sandy LuDepartment of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Karis YunDepartment of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Viveca GantiDepartment of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Raymond TsaoDepartment of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Xiaozhou ZhangDepartment of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Kenzy A MohamedDepartment of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Yul ChangDepartment of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Yucong GengDepartment of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Casey DaiDepartment of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Ashley K LiuDepartment of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Yee May LwinDepartment of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Heidi KimDepartment of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Vamsi SubravetiDepartment of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Narumi MitchellDepartment of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Na Youn JoDepartment of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Umais KhanDepartment of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA.
Roger Anguera-SinglaDepartment of Neurology, Neuroscape and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Zephyr WeinreichSwarthmore College, Swarthmore, PA 19081, USA.
Hanna E WillisCentre for Integrative Neuroimaging, Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford OX3 9DU, UK.
Holly BridgeCentre for Integrative Neuroimaging, Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford OX3 9DU, UK.
Michael P StrykerDepartment of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA.
Hillel AdesnikDepartment of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA.

Funding

DEVELOPMENT &PLASTICITY OF THE VISUAL SYSTEMR01EY002874 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STRYKER, MICHAEL P · 1986 to 2022
$6.4M
Excitation and Inhibition in Neural Circuits of the Visual CortexR01EY023756 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI Hillel Adesnik · 2013 to 2026
$6.1M
NEI NIH HHS R01 EY002874NEI NIH HHS R01 EY023756
6 · The paper itself

Abstract

The phenomenon of blindsight provides a unique opportunity to uncover brain areas important for conscious vision. Patients with blindsight lose the conscious experience of seeing while still being able to detect and locate visual stimuli. Blindsight occurs after damage to the primary visual cortex (V1). Rodents are likewise able to detect and locate visual stimuli after damage to V1, though whether they lose conscious vision as humans do is unclear. Here, we report the first mouse model of blindsight that provides evidence that removal of V1 causes mice to lose their putatively conscious vision. This loss occurs only if dLGN, a brain area in the thalamus that connects to V1, is damaged in addition to V1. We use this model to discover that suppressing the hippocampus acutely causes blindsight-like behavior. This suggests that the hippocampus functions in the intact brain to support conscious, but not unconscious, vision. Furthermore, while single, selective ablations of V1 or the hippocampus have only a minor effect on vision, simultaneous ablation causes blindsight-like behavior. These results suggest that V1 and the hippocampus can compensate for the permanent loss of the other for conscious vision, revealing a novel form of plasticity that supports conscious vision. Although never causally implicated in conscious visual perception, the hippocampus emerges as a candidate brain area critical for conscious experience. More broadly, this mouse model of blindsight will enable the interrogation and identification of the neural circuits that underlie conscious and unconscious vision.

Indexed as

BlindnessConsciousnessHippocampusPrimary Visual CortexVisual CortexVisual PerceptionAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLblindsightconsciousnessconscious visionhippocampusLGNperceptionsubjective experienceunconsciousnessV1vision

Identifiers

PMID41962536
PMCPMC13393572

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.