Evidence map›Paper›PMID 41962310›Full record

ReviewESMO open2026

New prognostic and predictive scoring systems for colorectal cancer liver metastases.

F Salvà, S Pérez Fernandez, C Dopazo, M Salcedo, N Saoudi, M Rodriguez, I Baraibar, J Ros, C Salva de Torres, C Vaghi and 6 more

Abstract readReview
In one paragraph

Review in ESMO open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

F SalvàDepartment of Medical Oncology, Vall Hebron University Hospital, Barcelona, Spain; Department of Medical Oncology, Vall Hebron Institute of Oncology (VHIO), Barcelona, Spain. Electronic address: fsalva@vhio.net.
S Pérez FernandezDepartment of Medical Oncology, Vall Hebron University Hospital, Barcelona, Spain; Department of Medical Oncology, Vall Hebron Institute of Oncology (VHIO), Barcelona, Spain.
C DopazoHepatobiliary and Transplant Surgery Unit, Vall Hebron University Hospital, Barcelona, Spain.
M SalcedoDepartment of Pathology, Vall Hebron University Hospital, Barcelona, Spain.
N SaoudiDepartment of Medical Oncology, Vall Hebron University Hospital, Barcelona, Spain; Department of Medical Oncology, Vall Hebron Institute of Oncology (VHIO), Barcelona, Spain.
M RodriguezDepartment of Medical Oncology, Vall Hebron University Hospital, Barcelona, Spain; Department of Medical Oncology, Vall Hebron Institute of Oncology (VHIO), Barcelona, Spain.
I BaraibarDepartment of Medical Oncology, Vall Hebron University Hospital, Barcelona, Spain; Department of Medical Oncology, Vall Hebron Institute of Oncology (VHIO), Barcelona, Spain.
J RosDepartment of Medical Oncology, Vall Hebron University Hospital, Barcelona, Spain.
C Salva de TorresDepartment of Medical Oncology, Vall Hebron University Hospital, Barcelona, Spain; Department of Medical Oncology, Vall Hebron Institute of Oncology (VHIO), Barcelona, Spain.
C VaghiDepartment of Medical Oncology, Vall Hebron Institute of Oncology (VHIO), Barcelona, Spain.
Z CalixtoDepartment of Pathology, Vall Hebron University Hospital, Barcelona, Spain.
C Gómez-GavaraHepatobiliary and Transplant Surgery Unit, Vall Hebron University Hospital, Barcelona, Spain.
M CaraltHepatobiliary and Transplant Surgery Unit, Vall Hebron University Hospital, Barcelona, Spain.
G SapisochinDepartment of General and Digestive Surgery, Vall Hebron University Hospital, Barcelona, Spain.
J TaberneroDepartment of Medical Oncology, Vall Hebron University Hospital, Barcelona, Spain.
E ElezDepartment of Medical Oncology, Vall Hebron University Hospital, Barcelona, Spain; Department of Medical Oncology, Vall Hebron Institute of Oncology (VHIO), Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer liver metastases (CRLM) remain a major therapeutic challenge, shaped by marked biological heterogeneity and unpredictable clinical outcomes. While classical Clinical Risk Scores (CRS) continue to inform surgical decision making, their static nature limits their relevance in an era defined by molecular profiling, dynamic biomarkers, and personalized therapy. Advances in genomics and liquid biopsy technologies have expanded the understanding of CRLM beyond traditional clinicopathological parameters, enabling real-time disease monitoring and more refined risk stratification. In parallel, dynamic scoring systems that incorporate evolving clinical and molecular data are redefining how risk is assessed and managed throughout the course of treatment. This review revisits classical CRS, explores emerging molecular and dynamic tools, and discusses their potential integration into clinical practice to improve patient selection, guide treatment timing, and refine the overall management of CRLM.

Indexed as

Colorectal NeoplasmsLiver NeoplasmsBiomarkers, TumorHumansPrognosisRisk AssessmentBiomarkers, TumorClinical Risk Scorescolorectal cancerhistological growth patternsliquid biopsyliver metastasesmolecular profiling

Identifiers

PMID41962310
PMCPMC13091191

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.