Evidence map›Paper›PMID 41962139›Full record

ArticleMolecular pharmaceutics2026

Nanostructured Lipid Carriers Enhance Brain Delivery and Antioxidant Efficacy of a Small-Molecule MAO B Inhibitor for Neurodegenerative Disease Therapy.

Rita Mastrogiacomo, Daniela Valeria Miniero, Mariagrazia Rullo, Federica Rizzi, Gianluca Minervini, Annamaria Panniello, Marinella Striccoli, Elisabetta Fanizza, Roberto Comparelli, Maria Lucia Curri and 5 more

Abstract read
In one paragraph

Article in Molecular pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Rita MastrogiacomoDepartment of Chemistry, University of Bari Aldo Moro, Via E. Orabona 4, Bari 70126, Italy.ORCID 0009-0007-2184-9205
Daniela Valeria MinieroDepartment Medicine and Surgery, LUM University Giuseppe Degennaro, Casamassima 70010, Italy.
Mariagrazia RulloDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Bari 70125, Italy.ORCID 0000-0001-5304-6764
Federica RizziInstitute for Chemical and Physical Processes (IPCF)-CNR SS Bari, Via Orabona 4, Bari 70126, Italy.ORCID 0000-0001-8891-4218
Gianluca MinerviniInstitute for Chemical and Physical Processes (IPCF)-CNR SS Bari, Via Orabona 4, Bari 70126, Italy.
Annamaria PannielloInstitute for Chemical and Physical Processes (IPCF)-CNR SS Bari, Via Orabona 4, Bari 70126, Italy.
Marinella StriccoliInstitute for Chemical and Physical Processes (IPCF)-CNR SS Bari, Via Orabona 4, Bari 70126, Italy.ORCID 0000-0002-5366-691X
Elisabetta FanizzaDepartment of Chemistry, University of Bari Aldo Moro, Via E. Orabona 4, Bari 70126, Italy.ORCID 0000-0001-6293-9388
Roberto ComparelliInstitute for Chemical and Physical Processes (IPCF)-CNR SS Bari, Via Orabona 4, Bari 70126, Italy.
Maria Lucia CurriDepartment of Chemistry, University of Bari Aldo Moro, Via E. Orabona 4, Bari 70126, Italy.ORCID 0000-0002-0261-8379
Marco CattoDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Bari 70125, Italy.ORCID 0000-0002-8411-304X
Grazia Maria LiuzziDepartment of Biosciences, Biotechnologies and Environment, University of Bari "Aldo Moro", Bari 70126, Italy.
Leonardo PisaniDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Bari 70125, Italy.ORCID 0000-0002-4198-3897
Tiziana LatronicoDepartment of Biosciences, Biotechnologies and Environment, University of Bari "Aldo Moro", Bari 70126, Italy.ORCID 0000-0001-6971-5416
Nicoletta DepaloInstitute for Chemical and Physical Processes (IPCF)-CNR SS Bari, Via Orabona 4, Bari 70126, Italy.ORCID 0000-0002-2107-2762

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodegenerative disorders, including Alzheimer's and Parkinson's diseases, urgently require new therapeutic strategies. Monoamine oxidase B (MAO B), a mitochondrial enzyme involved in oxidative stress and neurotransmitter metabolism, has emerged as a promising target for neuroprotection. A 5-substituted-1

Indexed as

AntioxidantsBrainDrug CarriersLipidsMonoamine Oxidase InhibitorsNanostructuresNeurodegenerative DiseasesAnimalsBlood-Brain BarrierCarbon Quantum DotsCell Line, TumorDrug Delivery SystemsHumansMonoamine OxidaseNeuroprotective AgentsAntioxidantsDrug CarriersLipidsMonoamine OxidaseMonoamine Oxidase InhibitorsNeuroprotective Agentsantioxidant activityblood–brain barrierMAO B inhibitornanostructured lipid carriersneurodegenerative diseases

Identifiers

PMID41962139
PMCPMC13147330

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.