Evidence map›Paper›PMID 41962022›Full record

ArticleThe Journal of urology2026

Generalized Sensory Sensitivity in Patients With Urinary Urgency-A LURN II Urinary Urgency Phenotyping Study.

H Henry Lai, Alan J Fossa, Brian Bieber, Cindy L Amundsen, J Eric Jelovsek, Anne P Cameron, Catherine Bradley, Karl Kreder, Claire C Yang, Alexander Glaser and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

H Henry LaiDepartment of Urology, Carver College of Medicine, University of Iowa, Iowa City, Iowa.
Alan J FossaArbor Research Collaborative for Health, Ann Arbor, Michigan.
Brian BieberArbor Research Collaborative for Health, Ann Arbor, Michigan.
Cindy L AmundsenDivision of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Duke University, Durham, North Carolina.
J Eric JelovsekDivision of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Duke University, Durham, North Carolina.
Anne P CameronDepartment of Urology, University of Michigan, Ann Arbor, Michigan.
Catherine BradleyDepartment of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa, Iowa City, Iowa.
Karl KrederDepartment of Urology, Carver College of Medicine, University of Iowa, Iowa City, Iowa.
Claire C YangDepartment of Urology, University of Washington, Seattle, Washington.
Alexander GlaserDivision of Urology, Department of Surgery, Endeavor Health, Evanston, Illinois.
Kimberly KentonSection of Urogynecology & Reconstructive Pelvic Surgery, Department of Obstetrics & Gynecology, University of Chicago, Chicago, Illinois.
J Quentin ClemensDepartment of Urology, University of Michigan, Ann Arbor, Michigan.
Victor P AndreevArbor Research Collaborative for Health, Ann Arbor, Michigan.
Ziya KirkaliNational Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland.
Steven E HarteChronic Pain and Fatigue Research Center, Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan.

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Continuation of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Data Coordinating CenterU24DK099879 · NIDDK · ARBOR RESEARCH COLLABORATIVE FOR HEALTH · PI GRAFF, JOHN JOSEPH · 2019 to 2025
$6.9M
Phenotype of urinary symptoms and relationships with genotype, sleep and obesityU01DK097779 · NIDDK · UNIVERSITY OF CHICAGO · PI GRIFFITH, JAMES WILLIAM, KENTON, KIMBERLY SUE · 2012 to 2025
$5.7M
Advancing the Measurement and Classification of Lower Urinary Tract DysfunctionU01DK097780 · NIDDK · DUKE UNIVERSITY · PI AMUNDSEN, CINDY, JELOVSEK, JOHN ERIC · 2012 to 2025
$5.3M
University of Iowa LURN Research SiteU01DK097772 · NIDDK · UNIVERSITY OF IOWA · PI BRADLEY, CATHERINE S, KREDER, KARL J · 2012 to 2025
$5.0M
Expansion of Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN)U01DK099879 · NIDDK · ARBOR RESEARCH COLLABORATIVE FOR HEALTH · PI MERION, ROBERT M · 2013 to 2018
$4.6M
University of Washington LURN Research SiteU01DK100011 · NIDDK · UNIVERSITY OF WASHINGTON · PI YANG, CLAIRE C · 2013 to 2025
$4.5M
University of Michigan LURN Research SiteU01DK099932 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CLEMENS, J. QUENTIN · 2013 to 2023
$4.4M
Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Second Phase StudyU01DK100017 · NIDDK · WASHINGTON UNIVERSITY · PI LAI, HING HUNG HENRY · 2013 to 2025
$3.9M
NCATS NIH HHS UL1 TR001422NIDDK NIH HHS U01 DK097772NIDDK NIH HHS U01 DK097779NIDDK NIH HHS U01 DK097780NIDDK NIH HHS U01 DK099879NIDDK NIH HHS U01 DK099932NIDDK NIH HHS U01 DK100011NIDDK NIH HHS U01 DK100017NIDDK NIH HHS U24 DK099879
6 · The paper itself

Abstract

purposeWe examined generalized sensory sensitivity (GSS) in patients with urinary urgency. MATERIALS AND

methodsAdult men and women who presented with urinary urgency, with or without urgency incontinence, and seeking treatment for their overactive bladder (OAB) were enrolled in the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) II Study. Controls without urgency or incontinence were enrolled. The GSS-Short Form (GSS-SF) questionnaire was used to assess self-reported sensitivity to external environmental stimuli (chemicals, bright lights, and sounds), sensitivity to internal bodily sensations (dry mouth, rapid heart rate, and balance), and the anatomical extent of body pain.

resultsSix hundred seventeen cases with urinary urgency and 125 controls were included. Cases had higher total GSS-SF scores (median 2 vs 0,

conclusionsPatients with urinary urgency had higher GSS compared with controls without urgency. Cases with higher GSS scores had more severe OAB symptoms and worse health-related quality of life. These findings suggest a subset of patients with urinary urgency may exhibit global, multisystem hypersensitivity to sensory input. In these individuals, bladder symptoms may represent a manifestation of broader sensory dysregulation rather than an isolated organ-specific pathology.

Indexed as

SensationUrinary Bladder, OveractiveUrinary Incontinence, UrgeAdultAgedCase-Control StudiesFemaleHumansMaleMiddle AgedPhenotypeSurveys and Questionnaireslower urinary tract symptomsoveractive bladderurinary incontinence

Identifiers

PMID41962022
PMCPMC13191568

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.