Evidence map›Paper›PMID 41961947›Full record

ArticleScience immunology2026

The rise of spatial TCR profiling: Emerging technologies and open challenges.

Yinglu Tang, Tao Wang

Abstract readComment
PubMed Publisher
In one paragraph

Article in Science immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Yinglu TangDepartment of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Tao WangDepartment of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-4355-149X

Funding

Applying deep learning to predict T cell receptor binding specificity of neoantigens and response to checkpoint inhibitorsR01CA258584 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI WANG, TAO, WANG, XINLEI · 2021 to 2025
$1.4M
Design and optimization of TCR-T therapeutics by an advanced T cell receptor-antigen binding prediction platformR41CA302099 · NCI · NIGHTSTAR BIOTECHNOLOGIES, INC · PI WANG, TAO · 2025 to 2025
$360k
NCI NIH HHS R01 CA258584NCI NIH HHS R41 CA302099
6 · The paper itself

Abstract

High-definition spatial TCR profiling illuminates how clonal identity and T cell state are coordinated in the tumor microenvironment (see related Research Article by McCord

Indexed as

Receptors, Antigen, T-CellT-LymphocytesAnimalsHumansTumor MicroenvironmentReceptors, Antigen, T-Cell

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.