Evidence map›Paper›PMID 41961929›Full record

ArticleScience advances2026

Regulation of autism-related self-injurious behavior by electrical stimulation of corticostriatal circuits in mice and humans.

Kristina Zhang, Jurgen Germann, Rafi Matin, Karim Mithani, Jacob Ellegood, Hrishikesh Suresh, Sammi Wong, Jason P Lerch, Brian J Nieman, Margot J Taylor and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kristina ZhangInstitute of Medical Science, University of Toronto, Toronto, Ontario, Canada.ORCID 0009-0003-8056-2272
Jurgen GermannKrembil Brain Institute, University Health Network, Toronto, Ontario, Canada.ORCID 0000-0003-0995-8226
Rafi MatinInstitute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
Karim MithaniNeurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-8094-3070
Jacob EllegoodMouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0003-1504-3321
Hrishikesh SureshNeurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0003-0412-5655
Sammi WongMouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0001-6644-7030
Jason P LerchMouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Brian J NiemanMouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0001-8914-3814
Margot J TaylorNeurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-3534-9750
Sara BreitbartDivision of Neurosurgery, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0009-0006-4162-2537
Alfonso FasanoInstitute of Medical Science, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-5346-0180
Carolina GorodetskyDivision of Neurology, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0003-0007-9591
Flavia Venetucci GouveiaNeurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0003-0029-1269
George M IbrahimInstitute of Medical Science, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-9068-8184

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysfunction of corticostriatal circuitry is related to the emergence of self-injurious behavior (SIB) in autism spectrum disorder (ASD). Despite mounting interest in circuit-based interventions for severe, refractory SIB, the lack of causal evidence linking modulation of corticostriatal networks to changes in SIB has limited the advancement of effective, targeted therapies. In this study, we demonstrate that electrical stimulation of the nucleus accumbens (NAcc) mitigates SIB and induces structural changes along corticostriatal circuits in a mouse model relevant for ASD and children with severe SIB undergoing NAcc-targeted deep brain stimulation. In BTBR

Indexed as

Autism Spectrum DisorderAutistic DisorderCerebral CortexCorpus StriatumDeep Brain StimulationSelf-Injurious BehaviorAnimalsChildDisease Models, AnimalElectric StimulationFemaleHumansMaleMiceNucleus Accumbens

Identifiers

PMID41961929
PMCPMC13068066

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.