Evidence map›Paper›PMID 41961856›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Many paths to destruction: Family-specific turnover and stress responses for tRNA introns.

Sara Metcalf, Regina T Nostramo, Alicia Bao, Katherine Clark, Paolo L Sinopoli, Anita K Hopper

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Sara MetcalfDepartment of Molecular Genetics, The Ohio State University, Columbus, OH 43210.
Regina T NostramoDepartment of Molecular Genetics, The Ohio State University, Columbus, OH 43210.
Alicia BaoDepartment of Molecular Genetics, The Ohio State University, Columbus, OH 43210.
Katherine ClarkDepartment of Molecular Genetics, The Ohio State University, Columbus, OH 43210.
Paolo L SinopoliDepartment of Molecular Genetics, The Ohio State University, Columbus, OH 43210.
Anita K HopperDepartment of Molecular Genetics, The Ohio State University, Columbus, OH 43210.

Funding

HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM122884
6 · The paper itself

Abstract

In organisms ranging from Archaea to humans, a subset of genes encoding tRNAs contain introns. Upon splicing, the tRNA exons are joined and the released free introns are rapidly degraded. Although tRNAs introns were previously considered to be "junk" sequences, we recently reported that free tRNA introns (fitRNAs) of

Indexed as

IntronsRNA, TransferSaccharomyces cerevisiaeStress, PhysiologicalOxidative StressRNA, FungalRNA SplicingRNA, FungalRNA, Transferenvironmental conditionsRNA turnoverstresstRNA introns

Identifiers

PMID41961856
PMCPMC13079951

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.