Evidence map›Paper›PMID 41961851›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Use of a cytochrome P450 humanized mouse model to refine schistosomiasis drug discovery.

Sarah D Davey, Josephine E Forde-Thomas, Benjamin J Hulme, Kristin Lees, Alice H Costain, Mary Evans, Gabriel Rinaldi, Laura Frame, Laste Stojanovski, Frederick R C Simeons and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Sarah D Davey *Department of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom.ORCID 0000-0001-8676-7330
Josephine E Forde-Thomas *Department of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom.ORCID 0000-0002-7202-3565
Benjamin J Hulme *Department of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom.ORCID 0000-0002-5638-6323
Kristin Lees *Department of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom.ORCID 0000-0002-9783-1227
Alice H CostainLydia Becker Institute of Immunology and Inflammation, Division of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, The University of Manchester, England, Manchester M13 9NT, United Kingdom.
Mary EvansDepartment of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom.
Gabriel RinaldiDepartment of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom.ORCID 0000-0002-7767-4922
Laura FrameDivision of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, United Kingdom.
Laste StojanovskiDivision of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, United Kingdom.
Frederick R C SimeonsDivision of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, United Kingdom.ORCID 0009-0001-4987-1742
Amy TavendaleDivision of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, United Kingdom.
A Kenneth MacLeodDivision of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, United Kingdom.
Remi PichonDepartment of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom.ORCID 0000-0002-5821-9529
Yi-Hsuan LeeDepartment of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom.ORCID 0009-0009-6530-6469
Oktawia PolakDepartment of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom.
Iain W ChalmersDepartment of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom.ORCID 0000-0001-8674-1181
Bismark DankwaDepartment of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom.ORCID 0000-0002-9174-5862
Brenda Kisia OdhiamboDepartment of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom.ORCID 0000-0001-6129-1583
Victor Hugo GuimaraesLaboratory of Inflammation and Infectious Diseases, Department of Morphology and Pathology, Federal University of São Carlos, São Carlos CEP 13565-905, Brazil.ORCID 0009-0003-0027-4140
Matthew HegartyDepartment of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom.
Martin T SwainDepartment of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom.
Wayne AubreyDepartment of Computer Science, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom.
Nicola CaldwellDivision of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, United Kingdom.
Andrew S MacDonaldLydia Becker Institute of Immunology and Inflammation, Division of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, The University of Manchester, England, Manchester M13 9NT, United Kingdom.ORCID 0000-0002-5356-1149
Ian H GilbertDivision of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, United Kingdom.ORCID 0000-0002-5238-1314
Beatriz BaragañaDivision of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, United Kingdom.ORCID 0000-0002-0959-1113
Kevin D ReadDivision of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, United Kingdom.ORCID 0000-0002-8536-0130
Karl F HoffmannDepartment of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom.ORCID 0000-0002-3932-5502

Funding

UK Research and Innovation (UKRI) MR/W013568/1Wellcome 222153/Z/20/Z
6 · The paper itself

Abstract

Control of schistosomiasis, a neglected tropical disease caused by infection with

Indexed as

Cytochrome P-450 Enzyme SystemDrug DiscoverySchistosoma mansoniSchistosomiasisSchistosomiasis mansoniAnimalsDisease Models, AnimalFemaleHumansLiverMiceMice, TransgenicPraziquantelCytochrome P-450 Enzyme SystemPraziquantelcytochrome P450drug discoveryhumanized mouseSchistosoma mansoni

Identifiers

PMID41961851
PMCPMC13079396

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.